EFFECTS OF ETHANOL ON METABOLIC CONTROL PROCESSES

乙醇对代谢控制过程的影响

• 批准号: 4687710
• 负责人: R L VEECH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687710
• 关键词: NAD(H) phosphate; acetaldehyde; acetates; alcohol dehydrogenase; alcoholic beverage consumption; alcoholism /alcohol abuse; aldehyde dehydrogenases; calcium; ethanol; fatty acid metabolism; glucose metabolism; liver metabolism; other phosphotransferase; pyrophosphates; starvation

Ethanol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde, and acetaldehyde is then further metabolized by aldehyde dehydrogenase to acetate. Most emphasis in the study of the metabolities of ethanol has focused on acetaldehyde. However, the blood concentration of this compound rarely exceeds 10 muM, while the blood concentration of acetate approaches 2 mM even after the consumption of moderate amounts of ethanol. This study was undertaken to elucidate the consequences of acetate metabolism on the major metabolic pathways. Administration of acetate to starved rats causes a number of changes in hepatic metabolite concentrations, the most striking of which are (1) a greater than one hundredfold elevation in pyrophosphate concentration, (2) a fivefold elevation in calcium, (3) a marked reduction in the cytosolic (NADP minus/plus)/(NADPH) redox ratio, and (4) a twofold increase in glucose concentration.

乙醇在肝脏中被乙醇脱氢酶代谢为 乙醛，然后乙醛进一步代谢为醛 脱氢酶转化为乙酸。 最重视代谢研究 乙醇的重点是乙醛。 但血药浓度 这种化合物的浓度很少超过 10 μM，而血液浓度 即使在消耗适量的醋酸盐后，醋酸盐仍接近 2 mM 乙醇。 进行这项研究是为了阐明以下后果： 乙酸代谢对主要代谢途径的影响。 给饥饿的老鼠注射醋酸盐会引起一些变化 肝脏代谢物浓度，其中最引人注目的是 (1) 焦磷酸盐浓度升高超过一百倍，(2) 钙含量增加五倍，(3) 细胞质显着减少 (NADP 减/加)/(NADPH) 氧化还原比，以及 (4) 两倍增加 葡萄糖浓度。