EFFECTS OF ETHANOL ON METABOLIC CONTROL PROCESSES

乙醇对代谢控制过程的影响

• 批准号: 4687710
• 负责人: R L VEECH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687710
• 关键词: NAD(H) phosphate; acetaldehyde; acetates; alcohol dehydrogenase; alcoholic beverage consumption; alcoholism /alcohol abuse; aldehyde dehydrogenases; calcium; ethanol; fatty acid metabolism; glucose metabolism; liver metabolism; other phosphotransferase; pyrophosphates; starvation

Ethanol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde, and acetaldehyde is then further metabolized by aldehyde dehydrogenase to acetate. Most emphasis in the study of the metabolities of ethanol has focused on acetaldehyde. However, the blood concentration of this compound rarely exceeds 10 muM, while the blood concentration of acetate approaches 2 mM even after the consumption of moderate amounts of ethanol. This study was undertaken to elucidate the consequences of acetate metabolism on the major metabolic pathways. Administration of acetate to starved rats causes a number of changes in hepatic metabolite concentrations, the most striking of which are (1) a greater than one hundredfold elevation in pyrophosphate concentration, (2) a fivefold elevation in calcium, (3) a marked reduction in the cytosolic (NADP minus/plus)/(NADPH) redox ratio, and (4) a twofold increase in glucose concentration.

乙醇被酒精脱氢酶在肝脏中代谢 然后，乙醛和乙醛被醛进一步代谢 脱氢酶至醋酸盐。 代谢的研究最重点 乙醇的重点是乙醛。 但是，血液浓度 这种化合物的血液浓度很少超过10个妈妈 乙酸盐接近2毫米，即使消耗中等量 乙醇。 这项研究是为了阐明 主要代谢途径上的乙酸代谢。 乙酸盐施用饥饿的大鼠会导致许多变化 肝代谢物浓度，其中最引人注目的是（1）A 焦磷酸盐浓度的升高大于一百倍，（2） 钙的升高五倍，（3）胞质的显着降低 （NADP负/plus）/（NADPH）氧化还原比，（4）增加了双重 葡萄糖浓度。