CHILDREN'S CANCER STUDY GROUP

儿童癌症研究小组

• 批准号: 3555775
• 负责人: FREDERICK B RUYMANN
• 金额: $ 23.6万
• 依托单位: CHILDREN'S HOSPITAL (COLUMBUS)
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3555775
• 关键词: 6 thiopurine; Ewing's tumor; Hodgkin's disease; Mycobacterium bovis; Wilms' tumor; acute leukemia; adolescence (12-20); asparaginase; azacitidine; bleomycin; bone marrow transplantation; brain neoplasms; cell differentiation; central nervous system neoplasms; child (0-11); cis platinum compound; combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; cytogenetics; cytosine arabinoside; dacarbazine; daunorubicin; doxorubicin; drug adverse effect; enzyme therapy; hematopoietic stem cells; hepatocellular carcinoma; histiocytic lymphoma; histiocytosis X; human subject; human therapy evaluation; lomustine; medical outreach /case finding; methotrexate; myelogenous leukemia; neoplasm /cancer chemotherapy; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer therapy; neuroblastoma; osteosarcoma; ovary neoplasms; pediatric neoplasm /cancer; poly IC; prednisone; procarbazine; retinoblastoma; rhabdomyosarcoma; splenectomy; testis neoplasms; vincristine

Columbus Children's Hospital (CCH) is a 313 bed pediatric facility and founding member of the Children's Cancer Study Group (CCSG). CCH serves as the Pathology Center for all CCSG studies. During 1987 CCH placed 60 new patients on first, second and new agent studies; in addition 72 patients were placed on special and epidemiological studies. Over the past five years CCH has placed 319 patients on CCSG first, second and new agent studies with an additional 254 patients on special and epidemiological studies. Approximately 1475 long term survivors of childhood cancer are followed at CCH. The overall survival of 481 patients treated at CCH in the past five years is 831 with a median follow-up of 2 1/2 years. Attesting to the significant progress in improved therapy for childhood cancer. CCH has a multidisciplinary participation within CCSG with 15 investigators having a high profile involvement and unique expertise in the areas of tumor pathology. rhabdomyosarcoma, neuroblastoma, and hystiocytosis-X. Other areas of involvement and key participation include partial splenectomy, neuropsych testing in ALL and pilot studies in ANLL, brain tumors, rhabdomyosarcoma and osteosarcoma. Two members of the Division of Hematology/Oncology represent CCSG on the Intergroup Rhabdomyosarcoma Study and have made valuable contributions in the pathology, treatment and basic research. During the past five years, individuals at CCH have authored or co-authored 104 publications or abstracts sponsored by CCSG. This averages over 20 publications/abstracts per year. Two affiliate institutions of CCH include Children's Medical Center in Dayton, Ohio and the Medical College of Ohio in Toledo. In November, 1987 the Wexner Institute of Pediatric Research (WIPR) was completed at CCH. Several investigators within the Division of Hematology/oncology have laboratory space in this facility. Special basic research expertise exists in neuroimmunology and bone marrow stem cell differentiation. CCH is expanding its capability in the area of marrow transplant. In cooperation with the Ohio State University School of Medicine an application to CCSG for official approval as a bone marrow transplant center is being prepared. CCH has been a long time contributor to expertise in pathology and therapeutic studies within CCSG. With an increased basic research capability at WIPR, CCH is looking forward to an expanded capability in basic science support of CCSG sponsored investigations.

哥伦布儿童医院（CCH）是313床儿科设施 以及儿童癌症研究小组（CCSG）的创始成员。 CCH是所有CCSG研究的病理中心。 期间 1987年CCH在第一，第二和新代理商上放置了60名新患者 研究；另外，将72名患者放置在特殊和 流行病学研究。 在过去的五年中，CCH已放置 319例CCSG的患者第一，第二和新的代理研究 另外254名特殊和流行病学研究的患者。 大约1475个儿童癌症的长期幸存者是 紧接着在CCH。 481例接受治疗的患者的总生存期 在过去五年中，CCH为831，中位随访为2 1/2 年。 证明改进治疗的重大进展 儿童癌。 CCH有多学科参与 在CCSG中，有15位调查人员有很高的参与 以及肿瘤病理领域的独特专业知识。 横纹肌肉瘤，神经母细胞瘤和Hystiocytosis-X。 其他领域 参与和关键参与包括部分脾切除术， 在ANLL，脑肿瘤中，所有人的神经心理测试和试点研究， 横纹肌肉瘤和骨肉瘤。 两名成员 血液学/肿瘤学代表组间的CCSG 横纹肌肉瘤研究，并在 病理，治疗和基础研究。 在过去的五个 多年来，CCH的个人撰写或合着了104 CCSG赞助的出版物或摘要。 这平均 每年20个出版物/摘要。 两个会员机构 CCH包括位于俄亥俄代顿的儿童医疗中心和 俄亥俄州医学院在托莱多。 1987年11月，韦克斯纳 儿科研究所（WIPR）在CCH完成。 血液学/肿瘤学分区内的几名研究者 在此设施中有实验室空间。 特别基础研究 神经免疫学和骨髓干细胞中存在专业知识 分化。 CCH正在扩大其在该领域的能力 骨髓移植。 与俄亥俄州立大学合作 医学院向CCSG申请正式批准 正在准备一个骨髓移植中心。 CCH一直在 长期为病理和治疗方面的专业知识的贡献者 CCSG中的研究。 具有提高的基础研究能力 在WIPR，CCH期待基本的扩展能力 CCSG赞助调查的科学支持。