CHILDRENS CANCER GROUP

儿童癌症组

• 批准号: 2607957
• 负责人: FREDERICK B RUYMANN
• 金额: $ 14.77万
• 依托单位: CHILDREN'S HOSPITAL (COLUMBUS)
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2607957
• 关键词: bone marrow transplantation; brain neoplasms; child (0-11); cis platinum compound; clinical trials; combination cancer therapy; combination chemotherapy; cooperative study; etoposide; histiocytosis X; human subject; human therapy evaluation; ifosfamide; neoplasm /cancer chemotherapy; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer radionuclide therapy; neoplasm /cancer surgery; neuroblastoma; neuropeptides; pediatric neoplasm /cancer; rhabdomyosarcoma; vincristine

Columbus Children's Hospital (CCH) is a 313-bed fully capable Children's Hospital, which has been a funded Childrens Cancer Group (CCG) institution since 1958. Dr. Frederick B. Ruymann has been the Principal investigator (PI) and CCG representative to the Intergroup Rhabdomyosarcoma Study (IRS) since November, 1982. The Division Of Hematology/Oncology is the Pediatric Component of the OSU-NCI funded Comprehensive Cancer Center and has an approved Hematology/Oncology Fellowship with 64 residents in pediatrics. CCH has served as the CCG-Pathology Center, which is now under the local direction of Dr. Stephen Qualman (Co-Investigator), a member of the CCG Pathology Steering Committee. Dr. William Newton is Director of the IRS Pathology Center at CCH. CCH celebrated its 100th year of operation in 1992 and is directed by Dr. Grant Morrow, III, the immediate Past-Chairman of the American Academy of Pediatrics. The CCH-CCG Network, which includes three other institutions in Ohio, The Medical College of Ohio (Toledo), The Childrens Medical Center/Wright Patterson AFB (Dayton), and The Cleveland Clinic Foundation (Cleveland), saw 274 newly diagnosed children and adolescents with malignancy in 1991. In 1992, not counting the Cleveland Clinic, 83 were placed on CCG therapeutic (Phase I/II) studies and 61 were placed on epidemiology or miscellaneous studies. From 1988-1992, there were 364 therapeutic and 302 special CCG entries by the CCH/CCG Network. CCH/CCG Network follows 343 CCG-long-term survivors of childhood cancer and an additional 267 survivors. CCH is an approved CCG Phase I/II (1990) and Bone Marrow Transplant (1992) institution under the direction of Drs. Anthony Cecalupo and Neena Kapoor (Co-Investigators) respectively. CCH's resident scientist, Sue O'Dorisio (MD/PhD/Co-Investigator) is a world expert on the neuropeptide regulation of neuroblastoma and a member of the CCG Neuroblastoma Strategy Committee. Other multidiscipline Co-Investigators on this grant include Dr. Allan Yates (Neuropathology), and Dr. Rick Pieters (Radiotherapy) who both have major roles in CCG science and leadership. CCH has made major contributions in diagnosis, treatment, and biology of histiocytosis X, rhabdomyosarcoma, brain tumors, and neuroblastoma, through CCG pilot and pre-clinical investigations. Current concept proposals for soft-tissue sarcomas, high-dose rate brachytherapy, and the neuropeptide regulation of neuroblastoma are before the appropriate CCG Strategy Committee for regional or groupwide study.

哥伦布儿童医院（CCH）是一家313张床的能力完全有能力的儿童 医院，曾是一家资助的儿童癌症组（CCG）机构 自1958年以来。弗雷德里克·B·鲁曼（Frederick B. （PI）和CCG代表组间横纹肌肉瘤研究（IRS） 自1982年11月以来。血液学/肿瘤学的分歧是 OSU-NCI资助的综合癌症中心和 拥有批准的血液学/肿瘤学研究金，有64位居民 儿科。 CCH曾担任CCG-PATHOLOGY CENTER，现在 在史蒂芬·Qualman（Stephen Qualman）博士（共同投资者）的地方指导下， CCG病理指导委员会成员。 威廉·牛顿博士是 CCH IRS病理中心主任。 CCH庆祝了其100年 1992年的运营，由格兰特·莫罗（Grant Morrow，III）指导， 美国儿科学会的直接前任院长。 CCH-CCG网络，其中包括俄亥俄州的其他三个机构， 俄亥俄州医学院（托莱多），儿童医疗中心/赖特 Patterson AFB（代顿）和克利夫兰诊所基金会（克利夫兰）， 1991年，有274名新诊断出患有恶性肿瘤的儿童和青少年。 1992年，不计算克利夫兰诊所，将83个放在CCG上 将治疗（I/II期）研究和61个研究放在流行病学或 其他研究。 从1988 - 1992年开始，有364个治疗方法和302 CCH/CCG网络的特殊CCG条目。 CCH/CCG网络遵循343 CCG长期的儿童癌症幸存者和另外267 幸存者。 CCH是批准的CCG I/II期（1990）和骨髓 Transplant（1992）在Drs的指导下制度。安东尼·塞卡卢波（Anthony Cecalupo） 和Neena Kapoor（共同投资者）。 CCH的居民 Sue O'Dorisio的科学家（MD/PHD/共同研究器）是世界专家 神经细胞瘤的神经肽调节和CCG成员 神经母细胞瘤战略委员会。 其他多学科共同研究者 这笔赠款包括艾伦·耶茨博士（神经病理学）和里克博士 彼得（放射疗法）在CCG科学和 领导。 CCH在诊断，治疗和 组织细胞增多症的生物学X，横纹肌肉瘤，脑肿瘤和 神经母细胞瘤，通过CCG试点和临床前研究。 当前的 软组织肉瘤，高剂量率近距离疗法的概念建议， 神经母细胞瘤的神经肽调节是在 适当的CCG策略委员会，用于区域或集体研究。