ADENOMATOUS COLONIC POLYPS--A VITAMERS AND MFO INDUCTION

腺瘤性结肠息肉--VITAMERS 和 MFO 诱导

基本信息

批准号：
3548362
负责人：
PHYLLIS Elaine BOWEN
金额：
$ 0.54万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-09-25 至 1986-11-30
项目状态：
已结题

项目摘要

This study seeks to demonstrate that low consumption of vitamin A compounds and/or marginal vitamin A status is associated with the development of colonic adenomatous polyps and/or colonic adenocarcinoma through a case-control study. The study will sort out by careful assessment of ingestion of preformed vitamin A and carotenoids the relative contribution of these A vitaminers to any protective effect observed. Vitamin A status will be assessed by plasma levels and a functional test for dark adaptation. The confounding variable of the level of induction of microsomal carcinogen metabolizing enzymes will also be investigated by measuring urinary D-glucaric acid excretion because vegetables containing high levels of carotene may also contain natural inducers of this enzyme system. A clinical trial using levels of beta-carotene which could be achieved by dietary intake alone will be instituted in subjects found to have adenomatous polyps and these patients will be followed for 3 years for development of polyps and health hazards associated with beta-carotene ingestion. The use of colonic adenomatous polyp formation, a precancerous condition, for a clinical trial has the advantage of having a short time for development and redevelopment occurs in a significant proportion of patients. The ultimate aim of this research is to assess the efficacy of the use of beta-carotene as a natural inhibitor of a particular form of cancer and the safety of luxus ingestion of beta-carotene with a view toward the formulation of valid National dietary advice concerning a protective diet against cancer.

这项研究旨在证明维生素A化合物的消耗量低和/或边缘维生素A状态与发展有关结肠腺瘤息肉和/或结肠腺癌通过病例对照研究。该研究将通过仔细评估摄入预制的维生素A和类胡萝卜素相对贡献在这些观察到的任何保护作用的维生素中。维生素A状态将通过血浆水平和黑暗的功能测试评估适应。诱导水平的混杂变量微粒体致癌代谢酶也将通过测量尿液D-葡萄糖酸排泄，因为含有蔬菜高水平的胡萝卜素也可能包含该酶的天然诱导剂系统。使用β-胡萝卜素水平的临床试验可能是仅通过饮食摄入来实现有腺瘤息肉，这些患者将被遵循3年与β-胡萝卜素相关的息肉和健康危害的发展摄取。使用结肠腺瘤息肉形成，一种癌症条件，对于临床试验，其优点是短时间用于开发和重建，发生在很大一部分患者。这项研究的最终目的是评估将β-胡萝卜素用作特定形式的天然抑制剂癌症和卢克斯摄入β-胡萝卜素的安全性为了制定有效的国家饮食建议保护性饮食抵抗癌症。