LONG TERM EFFECTS OF CHOLESTEROL LOWERING DIETS IN WOMEN

降低胆固醇饮食对女性的长期影响

• 批准号: 3356110
• 负责人: PHYLLIS Elaine BOWEN
• 金额: $ 38.26万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3356110
• 关键词: all trans retinol; apolipoproteins; atherosclerosis; biopsy; blood chemistry; blood lipid; blood lipoprotein; blood pressure; blood tests; body physical characteristic; carotenoids; cholesterol; circadian rhythms; coronary disorder; diet route /schedule; diet therapy; dietary fiber; dietary lipid; disease /disorder prevention /control; disease /disorder proneness /risk; electrofocusing; fatty acid biosynthesis; fatty acid metabolism; female; fluorescence spectrometry; gas chromatography; glutathione; health behavior; high density lipoproteins; high performance liquid chromatography; human subject; hypercholesterolemia; lipid peroxides; longitudinal human study; low density lipoprotein; menstrual cycle; nutrient requirement; nutrition related tag; pathogenic diet; platelets; radioimmunoassay; saturated fatty acids; thromboxanes; triglycerides; unsaturated fatty acids; urinalysis; very low density lipoprotein

Various low fat, low cholesterol and high fiber diets are being recommended for reducing coronary artery disease risk, yet few studies have evaluated the long-term effects of these diets in women with elevated serum cholesterol levels. This project will evaluate long-term effects of cholesterol-lowering diets in premenopausal women with cholesterol levels above 75th percentile for their group. We have developed four metabolic diets which are based on Phase 2 and Phase 3 of the American Heart Association Diet. Four studies, each 6 months in length, will be conducted to examine lipoprotein and other responses to these diets: 1) AHA Phase 3(20% fat, 100 mg/day cholesterol (C), P:S=2); 2) AHA Phase 2 (30% fat, 200 mg/day C, P:S=1); 3) AHA Phase 2 with P:S increased to 2: 4) AHA Phase 2 + fiber. Studies will be conducted in four consecutive years; one diet will be tested in each study. 24 volunteers will consume a "standard" American diet for one month and then one of the experimental diets for an additional five months. Of primary interest are changes in serum lipids and lipoproteins, platelet function, peroxide load and serum and tissue retinoids, carotenoids and tocopherols; postprandial lipemic and glycemic responses, as well as several measures of physiological well-being, will also be examined. The project is undertaken with the goal of providing sound evidence for dietary recommendations which are being made to the American people.

各种低脂，低胆固醇和高纤维饮食正在 建议降低冠状动脉疾病风险，但很少 研究已经评估了这些饮食中的长期影响 血清胆固醇水平升高的妇女。 这个项目将 评估降低胆固醇饮食的长期影响 胆固醇水平高于第75的胆固醇前妇女 他们小组的百分点。 我们已经开发了四种代谢 基于美国的第2阶段和第3阶段的饮食 心脏协会饮食。 四个研究，每6个月， 将进行检查脂蛋白和其他对 这些饮食：1）AHA第3期（20％脂肪，100 mg/天胆固醇（C）， p：s = 2）; 2）AHA阶段2（30％脂肪，200 mg/天C，p：s = 1）; 3）啊哈 P：S的2阶段增加到2：4）AHA阶段2 +纤维。 研究 将在连续四年内进行；一种饮食将是 在每项研究中进行了测试。 24个志愿者将消费“标准” 美国饮食一个月，然后是实验之一 饮食再五个月。 主要感兴趣的是 血清脂质和脂蛋白的变化，血小板功能， 过氧化物负荷，血清和组织类维生素，类胡萝卜素和 生育酚；餐后脂肪和血糖反应 作为生理健康的几种衡量标准，也将是 检查。 该项目的目的是提供 饮食建议的可靠证据正在 向美国人民做。

项目成果

Insulin-like growth factor I and low-density-lipoprotein cholesterol in women during high- and low-fat feeding.

高脂和低脂喂养期间女性的胰岛素样生长因子 I 和低密度脂蛋白胆固醇。

• DOI: 10.1093/ajcn/55.2.381
• 发表时间: 1992
• 期刊: The American journal of clinical nutrition
• 作者: Prewitt,TE;Unterman,TG;Glick,R;Cole,TG;Schmeisser,D;Bowen,PE;Langenberg,P
• 通讯作者: Langenberg,P

Changes in body weight, body composition, and energy intake in women fed high- and low-fat diets.

高脂肪和低脂肪饮食的女性体重、身体成分和能量摄入的变化。

• DOI: 10.1093/ajcn/54.2.304
• 发表时间: 1991
• 期刊: The American journal of clinical nutrition
• 作者: Prewitt,TE;Schmeisser,D;Bowen,PE;Aye,P;Dolecek,TA;Langenberg,P;Cole,T;Brace,L
• 通讯作者: Brace,L

Factor VII coagulant activity and cholesterol changes in premenopausal women consuming a long-term cholesterol-lowering diet.

长期降低胆固醇饮食的绝经前妇女的凝血因子 VII 活性和胆固醇变化。

• DOI: 10.1161/01.atv.14.8.1284
• 发表时间: 1994
• 期刊: Arteriosclerosis and thrombosis : a journal of vascular biology
• 作者: Brace,LD;Gittler-Buffa,C;Miller,GJ;Cole,TG;Schmeisser,D;Prewitt,TE;Bowen,PE
• 通讯作者: Bowen,PE

Differential reduction of plasma cholesterol by the American Heart Association Phase 3 Diet in moderately hypercholesterolemic, premenopausal women with different body mass indexes.

美国心脏协会第 3 阶段饮食对不同体重指数的中度高胆固醇血症、绝经前女性的血浆胆固醇有差异的降低。

• DOI: 10.1093/ajcn/55.2.385
• 发表时间: 1992
• 期刊: The American journal of clinical nutrition
• 作者: Cole,TG;Bowen,PE;Schmeisser,D;Prewitt,TE;Aye,P;Langenberg,P;Dolecek,TA;Brace,LD;Kamath,S
• 通讯作者: Kamath,S