Comparative and functional genomics of human bacterial pathogens

人类细菌病原体的比较和功能基因组学

• 批准号: nhmrc : 1008549
• 负责人: Prof Tim Stinear
• 金额: $ 40.11万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comparative-functional-genomics-bacterial-pathogens/109323
• 关键词: Comparative; functional; genomics; human; bacterial

Bacteria have evolved different ways of causing disease in humans. Some bacteria produce toxins that attack the host or they have developed ways to persist in the host by evading immune responses and resisting antibiotics. This project is concerned with understanding how these processes occur and developing preventative strategies for two important groups of bacteria that cause disease in humans, including the bacteria that cause TB and the devastating skin disease Buruli ulcer, and the hospital superbug "Golden Staph".

细菌已经进化出多种导致人类疾病的方式。一些细菌会产生攻击宿主的毒素，或者它们已经发展出通过逃避免疫反应和抵抗抗生素而在宿主体内持续存在的方法。该项目致力于了解这些过程是如何发生的，并针对引起人类疾病的两类重要细菌制定预防策略，包括引起结核病和毁灭性皮肤病布鲁里溃疡的细菌，以及医院超级细菌“金葡萄球菌”。