Multi-User Equipment to Refresh Underpinning Analytical Capabilities at the University of Warwick

多用户设备刷新华威大学的基础分析能力

• 批准号: EP/P030572/1
• 负责人: Pamela Thomas
• 金额: $ 254.61万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP030572%2F1
• 关键词: Multi; User; Equipment; Refresh; Underpinning

Our ability to rapidly and routinely obtain information about the composition, structure, morphology and function of molecules, materials and devices produced by man or by nature is central to many advances and breakthroughs in the Engineering and Physical Sciences (EPS). Therefore, the main aim of this proposal is to replace and upgrade obsolete or near end-of-life underpinning, multi-user equipment within our mass spectrometry, microscopy and device characterisation Facilities/Research Technology Platforms (RTP), to ensure that researchers at Warwick (UW) have access to a state-of-the-art Analytical Science (AS) infrastructure. UW's long-term excellence in AS is firmly rooted in strategic investment (e.g. people, equipment, infrastructure, training, etc.) in this underpinning field. The AS equipment requested includes:1) Four instruments for our Mass Spectrometry (MS) Facility, including an Inductively Coupled Plasma Mass Spectrometer, Gas Chromatography Quadrupole Mass Spectrometer, MicroTOF Focus and 3D ion trap Mass Spectrometer, which will increase both our analytical capacity and level of sensitivity.2) Three core workhorse microscopy devices from within our RTP programme: including a Transmission Electron Microscope, Atomic Force Microscope, and confocal Raman; allowing us to increase both our core analysis capacity through higher speed imaging, and improved image resolution.3) A Parameter Analyser and Probing System to be hosted within the University's Power Electronic Characterisation suite (PEATER), to enable both greater processing capacity and the analysis of devices at higher voltages and currents.The proposed AS equipment will be used to facilitate and strengthen a wide range of EPS research at UW, that falls within EPSRC's strategic remit and is comprehensively aligned to the research strategy of the University; contributing to core themes within the University's 'Global Research Priorities' (GRPs) including Energy, Innovative Manufacturing, Science and Technology for Health, and Materials. The new AS equipment will underpin the research of >50 academic groups from across four key departments (Chemistry, Physics, Engineering and WMG) within the Faculty of Science, working in diverse fields, including: catalysis, chemical and synthetic biology, energy materials, manufacturing, medical imaging, nanoparticles, nanocomposites, polymer materials, power electronics, semiconductors, structural engineering, synthetic organic and coordination chemistry. This investment in state-of-the art equipment will also be fundamental to facilitating the training of many M-Level undergraduates, MSc and PhD students, and early career researchers in cutting-edge AS techniques. Each Facility/RTP has well established programmes of user training and support, and these are open to all UW student and staff users. This training will also be offered to external academics and industry partners. UW is committed to ensuring that the equipment requested is effectively managed and maintained, and that usage is maximised across the University and by external research partners. The equipment will either be managed through shared Facilities (MS and PEATER), or through the appropriate RTP (Electron Microscopy and proposed Optical Spectroscopy) to which UW has provided significant investment. Overall, UW's contribution to its RTPs totals more than £8.84M (staff, equipment, maintenance and consumables) since their inception in 2014. Access will be advertised internally through the GRPs, and externally through Warwick Scientific Services (WSS) - a centre of excellence based at UW, delivering cutting-edge world class scientific services, technical measurement solutions, innovative translational research, and knowledge and training services to businesses that could benefit from expertise and instrumentation. It will also be listed on equipment.data, a national equipment sharing portal.

我们快速、常规地获取有关人类或自然产生的分子、材料和设备的组成、结构、形态和功能的信息的能力对于工程和物理科学（EPS）的许多进步和突破至关重要。该提案的目的是更换和升级我们的质谱、显微镜和设备表征设施/研究技术平台 (RTP) 内过时或接近报废的基础多用户设备，以确保华威大学 (UW) 的研究人员拥有最先进的分析科学 (AS) 基础设施 威斯康星大学在分析科学领域的长期卓越成就牢固地植根于该基础领域的战略投资（例如人员、设备、基础设施、培训等）。要求的设备包括：1) 用于我们的质谱 (MS) 设施的四台仪器，包括电感耦合等离子体质谱仪、气相色谱四极杆质谱仪、MicroTOF Focus 和3D 离子阱质谱仪，这将提高我们的分析能力和灵敏度水平。2) 我们的 RTP 计划中的三种核心主力显微镜设备：包括透射电子显微镜、原子力显微镜和共焦拉曼；通过更高速的成像和更高的图像分辨率来提高我们的核心分析能力。3) 参数分析仪和探测系统将托管在大学的电力电子表征套件 (PEATER) 中，以实现更好的处理拟议的 AS 设备将用于促进和加强威斯康星大学的广泛 EPS 研究，这属于 EPSRC 的战略职权范围，并与大学的研究战略全面一致；为大学“全球研究优先事项”(GRP) 的核心主题做出贡献，包括能源、创新制造、健康科学和技术以及材料。新的 AS 设备将支持来自四个学院的 50 多个学术小组的研究。理学院内的关键院系（化学、物理、工程和 WMG），从事不同领域的工作，包括：催化、化学和合成生物学、能源材料、制造、医学成像、纳米颗粒、纳米复合材料、聚合物材料、电力电子、半导体、结构工程、合成有机和配位化学方面的投资也对于促进许多 M 级本科生、硕士生和博士生以及早期职业研究人员在尖端 AS 技术方面的培训至关重要。 。每个Facility/RTP 拥有完善的用户培训和支持计划，这些计划向所有威斯康星大学学生和教职员工用户开放。该培训还将向外部学者和行业合作伙伴提供，威斯康星大学致力于确保所需的设备得到有效管理。并进行维护，并且该设备将通过共享设施（MS 和 PEATER）或通过威斯康星大学适当的 RTP（电子显微镜和拟议的光学光谱）进行管理。总体而言，自 2014 年成立以来，威斯康星大学对其 RTP 的贡献总计超过 884 万英镑（人员、设备、维护和消耗品）。访问将通过 GRP 在内部进行宣传，并通过华威科学服务公司 (WSS) 进行外部宣传。 ） - 位于威斯康星大学的卓越中心，为可以从专业知识和技术中受益的企业提供世界一流的科学服务、技术测量解决方案、创新转化研究以及知识和培训服务。它还将在国家设备共享门户 Equipment.data 上列出。

项目成果

Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex.

振动运动对有机金属络合物中甲基 C-H 的连续激活做出了重大贡献。

• DOI: http://dx.10.1021/acs.jpclett.0c03292
• 发表时间: 2021
• 期刊: The journal of physical chemistry letters
• 作者: Armstrong J

Experimental and theoretical evidence for unprecedented strong interactions of gold atoms with boron on boron/sulfur-doped carbon surfaces

金原子与硼/硫掺杂碳表面上前所未有的强相互作用的实验和理论证据

• DOI: 10.1039/d3na00956d
• 发表时间: 2023-12-11
• 期刊: Nanoscale Advances
• 影响因子: 4.7
• 作者: Samya Banerjee;J. Wolny;Mohsen Danaie;Nicolas P. E. Barry;Yisong Han;Houari Amari;Richard Beanl;Volker Schünemann;Peter J Sadler
• 通讯作者: Peter J Sadler

Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells.

癌细胞中半夹心有机锇前药积累的动力学分析。

• DOI: 10.1039/c9mt00173e
• 发表时间: 2019-10-16
• 期刊: Metallomics : integrated biometal science
• 作者: Annabelle Ballesta;F. Billy;J. Coverdale;Ji;C. Sanchez‐Cano;I. Romero‐Canelón;P. Sadler
• 通讯作者: P. Sadler

Transfer hydrogenation catalysis in cells.

细胞内转移氢化催化。

• DOI: http://dx.10.1039/d0cb00150c
• 发表时间: 2021
• 期刊: RSC chemical biology
• 影响因子: 4.1
• 作者: Banerjee S

Metallation-Induced Heterogeneous Dynamics of DNA Revealed by Single-Molecule FRET.

单分子 FRET 揭示金属化诱导的 DNA 异质动力学。

• DOI: http://dx.10.1002/chem.202000458
• 发表时间: 2020
• 期刊: Chemistry (Weinheim an der Bergstrasse, Germany)
• 作者: Berrocal