SYNTHESES OF MACROCYCLIC POLYAMINE LACTAMS

大环多胺内酰胺的合成

• 批准号: 3279321
• 负责人: HARRY H WASSERMAN
• 金额: $ 14.09万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-01-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3279321
• 关键词: alkaloids; antihypertensive agents; chemical synthesis; drug design /synthesis /production; heterocyclic compounds; lactams; macrolide antibiotics; polyamines; spermidine; spermine

The object of the proposed research will be to develop new methods for the synthesis of macrocyclic lactams, particularly polyamine lactams. Among the members of this group are the spermine and spermidine alkaloids. Our methods will include study of procedures for the successive ring expansion of smaller heterocyclic systems to form larger units. In another phase of this work we will investigate new methods for forming large rings which cn lead to lactams. We will also apply our procedures for forming macrocyclic systems to the synthesis of large bicyclic units containing hetero atoms capable of acting as cryptates for binding metal ions.

拟议研究的目的是开发新方法 大环内酰胺，特别是聚胺内酰胺的合成。 之中 该组的成员是精胺和亚精胺生物碱。 我们的 方法将包括连续环扩展程序的研究 较小的杂环系统形成较大的单元。 在这项工作的另一个阶段，我们将研究形成的新方法 cn 导致内酰胺的大环。 我们还将应用我们的程序 用于形成大环系统以合成大型双环单元 含有能够充当结合金属的穴状化合物的杂原子 离子。