Multi-User Equipment to Refresh Underpinning Analytical Capabilities at the University of Warwick

多用户设备刷新华威大学的基础分析能力

• 批准号: EP/P030572/1
• 负责人: Pamela Thomas
• 金额: $ 254.61万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP030572%2F1
• 关键词: Multi; User; Equipment; Refresh; Underpinning

Our ability to rapidly and routinely obtain information about the composition, structure, morphology and function of molecules, materials and devices produced by man or by nature is central to many advances and breakthroughs in the Engineering and Physical Sciences (EPS). Therefore, the main aim of this proposal is to replace and upgrade obsolete or near end-of-life underpinning, multi-user equipment within our mass spectrometry, microscopy and device characterisation Facilities/Research Technology Platforms (RTP), to ensure that researchers at Warwick (UW) have access to a state-of-the-art Analytical Science (AS) infrastructure. UW's long-term excellence in AS is firmly rooted in strategic investment (e.g. people, equipment, infrastructure, training, etc.) in this underpinning field. The AS equipment requested includes:1) Four instruments for our Mass Spectrometry (MS) Facility, including an Inductively Coupled Plasma Mass Spectrometer, Gas Chromatography Quadrupole Mass Spectrometer, MicroTOF Focus and 3D ion trap Mass Spectrometer, which will increase both our analytical capacity and level of sensitivity.2) Three core workhorse microscopy devices from within our RTP programme: including a Transmission Electron Microscope, Atomic Force Microscope, and confocal Raman; allowing us to increase both our core analysis capacity through higher speed imaging, and improved image resolution.3) A Parameter Analyser and Probing System to be hosted within the University's Power Electronic Characterisation suite (PEATER), to enable both greater processing capacity and the analysis of devices at higher voltages and currents.The proposed AS equipment will be used to facilitate and strengthen a wide range of EPS research at UW, that falls within EPSRC's strategic remit and is comprehensively aligned to the research strategy of the University; contributing to core themes within the University's 'Global Research Priorities' (GRPs) including Energy, Innovative Manufacturing, Science and Technology for Health, and Materials. The new AS equipment will underpin the research of >50 academic groups from across four key departments (Chemistry, Physics, Engineering and WMG) within the Faculty of Science, working in diverse fields, including: catalysis, chemical and synthetic biology, energy materials, manufacturing, medical imaging, nanoparticles, nanocomposites, polymer materials, power electronics, semiconductors, structural engineering, synthetic organic and coordination chemistry. This investment in state-of-the art equipment will also be fundamental to facilitating the training of many M-Level undergraduates, MSc and PhD students, and early career researchers in cutting-edge AS techniques. Each Facility/RTP has well established programmes of user training and support, and these are open to all UW student and staff users. This training will also be offered to external academics and industry partners. UW is committed to ensuring that the equipment requested is effectively managed and maintained, and that usage is maximised across the University and by external research partners. The equipment will either be managed through shared Facilities (MS and PEATER), or through the appropriate RTP (Electron Microscopy and proposed Optical Spectroscopy) to which UW has provided significant investment. Overall, UW's contribution to its RTPs totals more than £8.84M (staff, equipment, maintenance and consumables) since their inception in 2014. Access will be advertised internally through the GRPs, and externally through Warwick Scientific Services (WSS) - a centre of excellence based at UW, delivering cutting-edge world class scientific services, technical measurement solutions, innovative translational research, and knowledge and training services to businesses that could benefit from expertise and instrumentation. It will also be listed on equipment.data, a national equipment sharing portal.

我们迅速，常规地获得分子的信息，结构，形态和功能，本质上是由人本质上讲，这对于工程和物理科学的许多进步和突破至关重要（EPS）。在我们的质谱副本和设备表征设施/研究技术平台（RTP）中，生命的基础，多用户设备，以确保Warwick（UW）的研究人员可以使用最先进的分析科学。人，设备，基础设施，培训等）在此基础上所要求的设备。陷阱质谱仪L capace和灵敏度水平。2）来自我们的RTP程序中的三个核心工作试力显微镜设备：包括透射电子显微镜显微镜，以及共同的拉曼，允许我们增加我们的能力和Imagher Speed Speed Image参数分析仪和探测系统将成为托管的电力电子表征套件（PEATER）在较高电压和电流处对设备的限制能力分析。将用作设备的支撑物可用来促进和加强UW的广泛EPS研究，该研究属于EPSRC内的EPSRC。战略性的努力和综合性与THAE的研究策略相结合，促进了大学的“全球研究优先事项”（GRP）（包括能量，创新的手册）。来自四个关键部门IC，工程和WMG的学术团体在科学学院内，在各种领域工作，包括：催化，化学和合成生物学，能源材料，制造，医学成像，纳米颗粒，纳米复合材料，纳米复合材料，聚合物，聚合物材料，电力电子产品，ORS，结构工程。这项培训还将授予ED和外部研究合作伙伴的培训。 84万英镑（员工，设备，维护和消费）于2014年成立。埃伦斯（Ellence）位于UW，交付班级科学服务，技术测量解决方案，创新的透明度以及知识和培训服务，以可能性和工具。 。

项目成果

Transfer hydrogenation catalysis in cells.

• DOI: 10.1039/d0cb00150c
• 发表时间: 2021-02-01
• 期刊: RSC chemical biology
• 影响因子: 4.1
• 作者: Banerjee S;Sadler PJ
• 通讯作者: Sadler PJ

Metallodrugs are unique: opportunities and challenges of discovery and development.

• DOI: 10.1039/d0sc04082g
• 发表时间: 2020-11-12
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Anthony EJ;Bolitho EM;Bridgewater HE;Carter OWL;Donnelly JM;Imberti C;Lant EC;Lermyte F;Needham RJ;Palau M;Sadler PJ;Shi H;Wang FX;Zhang WY;Zhang Z
• 通讯作者: Zhang Z

Experimental and theoretical evidence for unprecedented strong interactions of gold atoms with boron on boron/sulfur-doped carbon surfaces

• DOI: 10.1039/d3na00956d
• 发表时间: 2023-12
• 期刊: Nanoscale Advances
• 影响因子: 4.7
• 作者: Samya Banerjee;J. Wolny;Mohsen Danaie;Nicolas P. E. Barry;Yisong Han;Houari Amari;Richard Beanland;Volker Schünemann;Peter J Sadler

Metallation-induced heterogeneous dynamics of DNA revealed by single-molecule FRET.

• DOI: 10.1002/chem.202000458
• 发表时间: 2020-01
• 期刊: Chemistry
• 作者: Raul Berrocal-Martin;C. Sanchez‐Cano;Cookson K. C. Chiu;R. J. Needham;P. Sadler;S. Magennis

Correction to "Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex".

更正“振动运动对有机金属络合物中的甲基 C-H 连续活化做出重大贡献”。

• DOI: 10.1021/acs.jpclett.3c00826
• 发表时间: 2023
• 期刊: The journal of physical chemistry letters
• 作者: Armstrong J