MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

少数民族高中生研究学徒计划

• 批准号: 3512239
• 负责人: MARGARITA ORTIZ-MARCIALES
• 金额: $ 3万
• 依托单位: UNIVERSITY OF PUERTO RICO AT HUMACAO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-03-01 至 1993-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3512239
• 关键词: minority institution research support

We are applying for the funds to purchase a much needed instrument, a Transmission Electron Microscope with the capabilities for distortion free imaging and high accelerating voltage for high contrast high magnification transmission electron microscopy. Utilizing immunoelectron microscopy and transmission electron microscopy aided morphometry of hearts, lungs and isolated cells we hope to gain new and useful information in the immunobiological reactions in the lung in response to oxygen toxicity, C5a induced inflammation and in hypertensive heart diseases. By utilizing immunoelectron microscopy we plan to study at molecular levels the assemblies of C5 convertase in the lung and the membrane attack complexes C5-9. Additionally, we will study the structural features of the cytolytic T cells and their interactions with the target tumor cells, as it pertains to their cytolytic granule content. These projects are NIH funded grants. Fulfillment of these research projects will be greatly enhanced by availability of the TEM requested. We also hope to obtain new information regarding the stoichiometry of C5-C5 convertase interactions and of the C5-C9 complex formation. Ultimate goal of all our research is to obtain data to provide useful information that can ultimately lead to development of preventive and therapeutic modes.

我们正在申请资金购买急需的资金 仪器，带有传输电子显微镜 无失真成像和高加速的功能 高对比度高放大率传输的电压 电子显微镜。 利用免疫电子显微镜和 透射电子显微镜协助心脏的形态计量学， 我们希望获得新的和有用的肺和孤立的细胞 肺中免疫生物学反应中的信息 对氧毒性的反应，C5A诱导炎症和 高血压心脏病。 通过利用免疫电子 显微镜我们计划在分子水平上研究组件 肺中的C5转化酶和膜攻击 复合物C5-9。 此外，我们将研究结构 细胞溶解T细胞的特征及其与 靶向肿瘤细胞，因为它与其细胞溶剂颗粒有关 内容。 这些项目是NIH资助的赠款。 实现这些 通过可用性，研究项目将大大增强 tem要求。 我们也希望获得新信息 关于C5-C5转化酶相互作用的化学计量法 和C5-C9复合物的形成。 我们所有研究的最终目标是获取数据以提供 有用的信息最终会导致发展 预防和治疗模式。