FEVER RESPONSE--PHYSIOLOGICAL/ECOLOGICAL ASPECTS

发烧反应——生理/生态方面

• 批准号: 3936814
• 负责人: ALAN E. MUCHLINSKI
• 金额: --
• 依托单位: CALIFORNIA STATE UNIVERSITY LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3936814
• 关键词: Anura; Chelonia; epizootiology; field study; hyperthermia; laboratory rabbit; lizards; oxygen consumption; snakes; telemetry

The research described in this proposal aims to increase our knowledge concerning the fever response in animals other than humans; specifically relating to the occurrence of the fever response in one species of amphibian and two species of mammals living in their natural environment, the generality of the fever response in reptiles, and the energetic cost of the fever response in a free-living reptile. All of the studies concerning the fever response has never been demonstrated or investigated under natural field conditions where the greater heterogeneity of biotic and abiotic factors may lead to a more complex response. Also, although the fever response has been demonstrated in a number of ectothermic vertebrates under laboratory conditions, no systematic study of the fever response has been undertaken with any specific taxonomic group of ectothermic vertebrates to demonstrate the generality of the response and its relationship to life history characteristic of a species. Data on the fever response of the bullfrog, the California Ground squirrel, and the desert cottontail rabbit will first be gathered in the laboratory and than the laboratory baseline data will be applied to experiments on free-living animals. Body temperatures will be determined with the use of temperature sensitive radio transmitters. In the survey of the Class Reptilia for the fever response, II species representing 7 different Families will be given injections of heat-killed Aeromonas hydrophila, a gram negative bacterium known to be pathogenic to reptiles. The reptilian species to be used represent animals from different habitats (aquatic, mesic, desert), with different food habits (herbivorous, insectivorous, carnivorous), and with different activity patterns (diurnal, nocturnal). In the section that pertains to the energetic cost of the fever response, time budget analysis and oxygen consumption measurements will be combined to yield an estimate of the energetic cost of the fever response in a free-living reptile; the chuckwalla.

该提案中描述的研究旨在增加我们的 关于动物以外的动物发烧反应的知识 人类特别与发烧的发生有关 一种两栖动物和两种哺乳动物的反应 生活在自然环境中，发烧的一般性 爬行动物的反应以及发烧反应的能量成本 在自由生活的爬行动物中。 有关发烧的所有研究 在自然中从未证明或调查过响应 生物和生物异质性较高的现场条件 非生物因素可能导致更复杂的响应。 还， 尽管发烧反应已在许多 在实验室条件下的热热脊椎动物，没有系统的 对发烧反应的研究已经进行了任何特定的 分类脊椎动物的分类组，以证明 反应的一般性及其与生活历史的关系 物种的特征。 有关加利福尼亚地面牛蛙的发烧反应的数据 松鼠和沙漠棉尾兔将首先聚集 在实验室和实验室基线数据中将是 应用于自由活动动物的实验。 体温 将通过使用温度敏感无线电来确定 发射器。 在对发烧的班级爬行动物的调查中 响应，代表7个不同家庭的ii物种是 给定热杀死的空气负气管的水真相，一克 负细菌已知是爬行动物的致病性。 这 爬行动物物种代表来自不同的动物 栖息地（水生，中间，沙漠），有不同的食物习惯 （草食性，食虫性，食肉动物），并且有不同的 活动模式（昼夜，夜间）。 在该部分 与发烧反应的充满活力的成本有关，时间预算 分析和氧气消耗测量将合并为 得出对发烧反应的能量成本的估计 自由生活的爬行动物； Chuckwalla。