ULTRA-COMPACT N-13 AMMONIA GENERATOR FOR PET

适用于宠物的超紧凑型 N-13 氨发生器

• 批准号: 3502293
• 负责人: RUTH E SHEFER
• 金额: $ 5万
• 依托单位: SCIENCE RESEARCH LABORATORY, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502293
• 关键词: ammonia; biomedical automation; biomedical device power system; biomedical equipment development; clinical biomedical equipment; nitrogen; particle accelerators; positron emission tomography; radiation protection; radiochemistry; radionuclides; radiopharmacology

The objective of this program is to develop a dedicated, accelerator-based 13N-ammonia delivery system for positron emission tomography (PET). 13N- ammonia PET scans can accurately measure myocardial blood flow and have been shown to be valuable tools in diagnosing coronary artery disease. 13N-ammonia can also be utilized to measure blood flow in other parts of the body, including the liver, kidney, brain and malignant tumors. The proposed generator will utilize a very low energy Coaxial Cascade Accelerator (CCA) developed at SRL to produce 13N via the 12C(d,n)13N nuclear reaction. The fully shielded acceleratory and 13N-ammonia production system will be housed in a 1.8 m x 1 m x 1.2 m enclosure and will be fully automated with easily operated push-botton controls. The estimated cost of the 13N-ammonia delivery system is comparable to that of a one of a one year supply of 82 Rb, another commonly used blood flow agent.

该计划的目的是开发一个专用的，基于加速器的人 正电子发射断层扫描（PET）的13N- ammonia递送系统。 13n- PET扫描可以准确测量心肌流动，并具有 被证明是诊断冠状动脉疾病的宝贵工具。 也可以利用13n- ammonia来测量 身体，包括肝脏，肾脏，脑和恶性肿瘤。 这 提议的发电机将使用非常低的能量同轴级联 加速器（CCA）在SRL开发，通过12C（d，n）13N生产13N 核反应。 完全屏蔽的加速度和13n- ammonia 生产系统将安置在1.8 m x 1 m x 1.2 m的外壳中，并且 将通过易于操作的按钮控件完全自动化。 这 13N- ammonia交付系统的估计成本与 一年的82 rb供应中的一个，另一种常用的血流 代理人。