IMPLANTABLE HOLLOW FIBER GLUCOSE SENSOR

植入式中空纤维血糖传感器

• 批准号: 3507293
• 负责人: Elsa M Janle
• 金额: $ 25.81万
• 依托单位: ASH MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507293
• 关键词: biomaterial evaluation; blood chemistry; blood glucose; clinical biomedical equipment; disease /disorder model; glucose; histology; hollow fiber separation technique; home health care; hospital patient care; implant; interstitial; monitoring device; ultrafiltration

We propose to develop two closely related devices which will improve home and hospital monitoring of glucose for diabetes. The common element of both devices is a fiber which is implanted subcutaneously. A negative pressure is applied to this fiber to withdraw tissue fluid. In the ambulatory model the fluid will be collected and analyzed using one of the currently available blood glucose strips and a reflectance meter. Since painful finger pricks are eliminated, glucose values can be obtained as often as is necessary to maintain good control. In the hospital model the fluid will be analyzed directly by an optical system. This hospital model will allow constant monitoring of blood glucose without any delay between drawing the sample and obtaining the results. The aims of this project are to build and test these glucose sensing devices in vitro and in vivo in dogs. These devices will have significant commercial potential. The potential market for the ambulatory devices is the population of insulin dependent diabetics. The hospital model provides an inexpensive system for constant monitoring. Other instruments which monitor constantly are very expensive and therefore currently available only in the largest hospitals. In addition the system we are developing has the potential to be adapted for constant monitoring of many other tissue constituents, including drug levels.

我们建议开发两种密切相关的设备 改善家庭和医院对糖尿病血糖的监测。 这两种设备的共同元件是光纤 植入皮下。 对此施加负压 纤维抽取组织液。 在动态模型中，液体 将使用当前的其中一种来收集和分析 可用血糖试纸和反射计。 自从 消除手指刺痛，血糖值可以 为了保持良好的控制，尽可能频繁地获取。 在 医院模型中的液体将由一个直接分析 光学系统。 这种医院模式将允许不断 两次抽血之间没有任何延迟地监测血糖 样品并获得结果。 该项目的目标 将在体外和体内构建并测试这些葡萄糖传感装置 狗体内。 这些设备将具有巨大的商业潜力。 这 流动设备的潜在市场是 胰岛素依赖型糖尿病患者。 医院模式提供了 用于持续监控的廉价系统。 其他仪器 持续监控非常昂贵，因此 目前仅在最大的医院提供。 此外 我们正在开发的系统有潜力适应 持续监测许多其他组织成分，包括 药物水平。