SUBCUTANEOUS INFUSION ACCESS DEVICE

皮下输液装置

• 批准号: 3495796
• 负责人: Elsa M Janle
• 金额: $ 5万
• 依托单位: ASH MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-19 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3495796
• 关键词: artificial endocrine pancreas; biomaterial development /preparation; biomaterial evaluation; blood chemistry; blood glucose; cytosine arabinoside; diabetes mellitus therapy; disease /disorder model; dogs; drug administration routes; drug delivery systems; fluid flow; insulin; insulin dependent diabetes mellitus; laboratory rat; membrane permeability; neoplasm /cancer chemotherapy; pharmacokinetics; polymers; radioimmunoassay; ultrafiltration

Continuous subcutaneous insulin infusion has become an important method of treating insulin dependent diabetics because the better glucose control achievable by this method could potentially reduce the morbidity and mortality associated with the disease. Current subcutaneous access is via a needle taped in place. The Subcutaneous Infusion Access Device (SIAD) is a small implantable device which can be inserted under the skin through a 13 gauge needle. Implantation can be done under local anesthesia. An insulin pump can be connected to it and it provides continuous access to the subcutaneous tissue for 6 months. The materials of the SIAD and soft are therefore more comfortable than a needle continuously inserted into the skin. Once the tissue has grown into the transcutaneous cuff material and formed a continuous barrier, there is less chance of infection than from a needle. The design of the SIAD will be developed using in vitro infusion studies. It will then be tested in diabetic dogs. The increased comfort and safety provided by this device to patients using insulin pumps should make this method of treatment more acceptable to greater numbers of insulin dependent diabetics.

持续皮下注射胰岛素已成为重要的治疗手段 治疗胰岛素依赖型糖尿病的方法，因为效果更好 通过这种方法实现的血糖控制可能会减少 与该疾病相关的发病率和死亡率。 当前的 皮下通路是通过用胶带固定到位的针进行的。 这 皮下输液接入装置 (SIAD) 是一种小型植入式输液装置 可通过 13 号规格插入皮下的装置 针。 植入可以在局部麻醉下进行。 一个 胰岛素泵可以连接到它并提供连续的 进入皮下组织6个月。 的材料 因此，SIAD 和软质比针更舒适 不断地插入皮肤。 一旦组织生长 进入经皮袖带材料并形成连续的 屏障，感染的机会比针头少。 SIAD 的设计将利用体外输注进行开发 研究。 然后将在患有糖尿病的狗身上进行测试。 该设备提供了更高的舒适度和安全性 使用胰岛素泵的患者应按此方法治疗 更容易被更多胰岛素依赖型糖尿病患者接受。