Closed-loop insulin delivery compared with islet cell transplantation for adults with type 1 diabetes and impaired awareness of hypoglycaemia

闭环胰岛素输送与胰岛细胞移植治疗成人 1 型糖尿病且低血糖意识受损的比较

• 批准号: nhmrc : GNT1150537
• 负责人: Dr Melissa Lee
• 金额: $ 9.15万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/closed-loop-insulin-awareness-hypoglycaemia/1348934
• 关键词: Closed; loop; insulin; delivery; compared

Hypoglycaemia in adults with type 1 diabetes is common. Evaluation of therapies – the ‘artificial pancreas’ and islet cell transplantation - is warranted in a cohort with repeated episodes of hypoglycaemia. This proposal will assess whether the ‘artificial pancreas’ and islet cell transplantation, compared with usual insulin therapy, will reduce hypoglycaemia and improve other clinical outcomes over 6 months. This has potential to expand therapies used in current clinical practice.

成人 1 型糖尿病患者的低血糖很常见，在低血糖反复发作的队列中，有必要对“人工胰腺”和胰岛细胞移植进行治疗。与常规胰岛素治疗相比，6 个月内可降低低血糖并改善其他临床结果，这有可能扩大当前临床实践中使用的治疗方法。