AUTOMATIC CONTROL OF EXTRACORPOREAL LIFE SUPPORT

自动控制体外生命支持

• 批准号: 3502363
• 负责人: Scott I Merz
• 金额: $ 5万
• 依托单位: MC3, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-12 至 1993-11-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502363
• 关键词: automated data processing; bioengineering /biomedical engineering; biomedical automation; blood circulation; blood oxygenator; carbon dioxide transport; clinical biomedical equipment; computer data analysis; computer program /software; computer system design /evaluation; extracorporeal circulation; hemodynamics; oxygen transport; respiratory oxygen

An automatic control system for extracorporeal gas exchange support is presented. A microcomputer-based data acquisition, analysis, and feedback control system will be developed to control extracorporeal oxygen delivery (by adjusting extracorporeal blood flow) and carbon dioxide removal (by adjusting gas flow through the oxygenator). Such a system is expected to improve the efficacy of oxygen delivery to the patient, maintain metabolic levels with more precision than the manually-controlled system, and provide for automatic weaning of extracorporeal support as patient condition improves. Prolonged extracorporeal life support currently requires continuous supervision in the intensive care unit by a specially-trained technician. Such supervision is very expensive, and limits the number of patients who can be supported, due to the finite number of technicians at each hospital. An automatic control system would enable one technician to oversee more than one case simultaneously. An automatic control scheme will be developed and tested using continuous recordings of data from patients during extracorporeal gas exchange support. The system will be tested with an in vitro patient model, during simulations of events possible during support, such as oxygenator failure and changes in patient oxygen requirements.

用于体外气体交换支持的自动控制系统是 提出。 基于微型计算机的数据采集，分析和 将开发反馈控制系统以控制体外 氧气递送（通过调节体外血流）和碳 去除二氧化物（通过调节通过氧合剂的气体流动）。 这样的 预计系统将提高氧气递送到 患者，保持代谢水平的精度比 手动控制系统，并提供自动断奶 随着患者状况的改善，体外支持会得到改善。 延长的体外生活支持目前需要连续 专门训练的技术人员在重症监护病房的监督。 这样的监督非常昂贵，并限制了 由于每个技术人员数量有限，因此可以支持 医院。 自动控制系统将使一名技术人员能够 同时监督多个案例。 将使用连续的自动控制方案开发和测试 体外气体交换期间患者的数据记录 支持。 该系统将通过体外患者模型进行测试， 在支持期间可能发生的事件的模拟过程中，例如充氧剂 失败和患者氧气需求的变化。