SURFACE MODIFICATION TO IMPROVE BREAST PROSTHESES

表面修饰以改进乳房假体

• 批准号: 3492929
• 负责人: DAVID L CLAPPER
• 金额: $ 5万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1993-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3492929
• 关键词: biomaterial development /preparation; biomaterial evaluation; biomaterials; collagen; contracture; extracellular matrix proteins; histocompatibility; histology; implant; mammary gland; photochemistry; polymers; radiotracer; silicone rubber; swine; tissue /cell culture

The greatest problem with current breast prostheses is the development of a contractile fibrous capsule. Capsular contracture produces breast hardening, pain, and distortion of the breast shape. This SBIR Phase I project proposes to combine two types of prosthesis surface modifications to reduce capsule formation and contracture. First, the prosthesis to be used will have a textured (porous) silicone rubber surface. Porous polymers are reported to improve tissue integration, decrease the size of fibrous capsules formed, and inhibit the ordered formation of collagen/myofibril layers that are typical of contracted capsules. Second, the textured surface will be coated with extracellular matrix (ECM) proteins and/or peptides to further improve tissue integration by promoting the attachment and ingrowth of breast tissue. Radiolabelled ECM proteins and peptides will be used to optimize immobilization efficiency on the prostheses, and their bioactivity will be evaluated in vitro by quantitating the attachment and growth of fibroblasts and epithelial cells. Coated prostheses will be implanted subcutaneously into pigs and histologically evaluated for tissue integration and fibrous encapsulation. Mammary prostheses are the most commonly used synthetic implants in the United States, and about 30% of these prostheses encounter significant problems with capsular contracture. Therefore, prostheses modifications that reduce the incidence of this problem would be extremely beneficial.

当前乳房假体的最大问题是发展 收缩纤维胶囊。 囊闭合会产生乳房 乳房形状的硬化，疼痛和扭曲。 这个SBIR阶段 项目提议结合两种类型的假体表面修饰 减少胶囊的形成和缔合。 首先，假体是 使用的将具有质感（多孔）硅胶橡胶表面。 多孔 据报道，聚合物可以改善组织的整合，减少 形成纤维胶囊，并抑制有序的形成 胶原蛋白/肌原纤维层是典型的收缩胶囊。 第二， 纹理表面将涂有细胞外基质（ECM） 蛋白质和/或肽通过促进进一步改善组织整合 乳腺组织的附着和向内生长。 放射性标记的ECM蛋白和肽将用于优化 假体的固定效率及其生物活性将是 通过定量成纤维细胞的附着和生长来评估体外评估 和上皮细胞。 涂层假肢将被皮下植入 进入猪，并通过组织学评估组织整合和纤维 封装。 乳腺假体是最常用的合成植入物 美国，其中约30％的假体遇到了重要的 囊闭合问题的问题。 因此，修改假体 这降低了这个问题的发生将是非常有益的。