CIRCULATORY AND METABOLIC ADJUSTMENTS AT BIRTH

出生时的循环和代谢调整

• 批准号: 3486089
• 负责人: ABRAHAM M RUDOLPH
• 金额: $ 25.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-01-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3486089
• 关键词: body temperature regulation; brain circulation; brain metabolism; carbohydrate metabolism; cardiac output; catecholamines; embryo /fetus; fatty acid metabolism; gastrointestinal circulation; heart circulation; heart metabolism; heart rate; hemodynamics; hormone regulation /control mechanism; kidney circulation; kidney metabolism; newborn animals; respiratory gas level; respiratory oxygenation; sheep; thyroid hormones

Although various physiological and biochemical functions have been studied in fetal and in neonatal mammals, the role of the individual components of the birth process in inducing the changes which occur after birth, have not been well delineated. In this project, it is planned to examine the role of some of the events which occur at birth on circulatory, metabolic, and hormonal adjustments. The studies will be conducted in chronically-instrumented fetal lambs, in utero, and various perinatal events will be simulated. These include the effects of: 1) pulmonary ventilation in utero, with no change in blood gases, 2) ventilation with air or oxygen to increase arterial saturation to postnatal levels, 3) umbilical cord occlusion, 4) body cooling without stimulating cutaneous receptors, 5) surface cooling, and 6) combination of ventilation, oxygenation, and cooling. The effects of these events on the following will be studied: a) general circulatory responses including heart rate, intracardiac flows and cardiac output and its distribution, b) hormonal responses, particularly of catecholamines and thyroid hormones, c) metabolism of carbohydrate and fatty acids, d) myocardial blood flow and metabolism, and g) gastrointestinal blood flow and metabolism.

尽管各种生理生化功能已被研究 在胎儿和新生哺乳动物中，各个成分的作用 出生过程引起出生后发生的变化，但尚未 被很好地描绘出来。 在这个项目中，计划检查角色 出生时发生的一些有关循环、代谢和 荷尔蒙调整。 研究将在 长期接受仪器检测的胎儿羔羊，在子宫内，以及各种围产期 事件将被模拟。 这些影响包括： 1) 肺部 子宫内通气，血气无变化，2) 通气 空气或氧气将动脉饱和度提高到产后水平，3) 脐带结扎，4）身体降温，不刺激皮肤 接收器，5) 表面冷却，以及 6) 通风组合， 充氧、冷却。 这些事件对以下方面的影响 将研究：a）一般循环反应，包括心率， 心内流量和心输出量及其分布，b) 激素 反应，特别是儿茶酚胺和甲状腺激素的反应，c) 碳水化合物和脂肪酸的代谢，d) 心肌血流量和 代谢，g) 胃肠道血流和代谢。