EPSRC-NIHR HTC Partnership Award 'Plus': IMPRESS

EPSRC-NIHR HTC 合作伙伴奖“Plus”：IMPRESS

基本信息

批准号：
EP/N027345/1
负责人：
Peter Culmer
金额：
$ 64.34万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN027345%2F1
关键词：
EPSRC NIHR HTC Partnership Award

项目摘要

IMPRESSPlus has been designed to maximise and extend the impact of the current IMPRESS network by applying engineering sciences to deliver novel solutions to the many challenges that exist in the management and treatment of incontinence. There is a critical lack of scientific research in this area compared to areas such as vascular, cardiac and orthopaedic healthcare - each of which have shown huge gains through the application of focussed basic and translational science.Faecal Incontinence (FI) is defined as the inability to fully control the passage of faeces through the anus. This may arise due to a weakened anal sphincter muscle (typically following child birth), problems with nerve supply (e.g. stroke, multiple sclerosis), or in association with other gastrointestinal conditions (e.g. irritable bowel syndrome). It is a common and distressing condition that causes shame, embarrassment, depression, social isolation, secrecy, poor self-esteem, and sexual avoidance. As a result, more than 54% of patients with FI have not discussed their symptoms with a physician , and only one-quarter of patients with FI are referred by their GP for specialist treatment . Its exact prevalence is difficult to determine but best estimates suggest that in the adult population it is around 10%, and that 0.5% - 1% below 65 years and 3% - 8% over 65 years' experience regular faecal incontinence. Urinary Incontinence (UI) is defined as involuntary leakage of urine, UI presents a major burden on NHS resources. It is a common and distressing condition, which impacts of quality of life. The main forms of UI are stress incontinence (SUI), which is leakage with physical exertion, and urge incontinence (UUI), which is leakage with a strong desire to void. Mixed urinary incontinence is a combination of SUI and UUI. The prevalence of UI increases with age and is higher in institutionalised adults, who tend to be older and suffer associated co-morbidity. It is more often a problem for females, with prevalence rates of UI ranging from 4.5% to 53% in women, as compared to 1.5% and 24% in men. Although previously considered in isolation, it is increasingly recognised that many forms of FI and UI share a common underlying pathophysiology and frequently co-exist with pelvic organ prolapse.Incontinence places a massive burden on the NHS and impacts significantly on quality of life for thousands of patients in the UK. Whilst many areas of medical engineering share a growth in the engagement of engineers and scientists to push forward the exploitation of emerging technologies it is arguably the case that the nature of this disease prevents engineering and science research leaders seeing the potential for some rich research challenges. To date the IMPRESS network has been successful in fulfilling its objectives of increasing the number of leading UK technologists (from academia and industry) that are engaged with research into the clinical changes associated with incontinence. This is demonstrated through a range of exciting new collaborative projects that have arisen from IMPRESS workshops and events and have been supported by competitive pump-priming funding from the network. IMPRESSPlus will secure the legacy of the existing IMPRESS network. This will be achieved by:1) strategically supporting emerging research with feasibility project funding 2) running international IMPRESSPlus conference workshops to build the network3) using a researcher secondment scheme to aid knowledge-transfer with industry and leading international research centres4) disseminating the networks findings to researchers, patients, healthcare providers and policy makers5) identifying long-term funding for the network and its researchIn summary, through the IMPRESS network we aim to resolve the current impasse that stifles innovation and translation of new engineering technologies for the management, treatment and prevention of incontinence.

ImpressPlus旨在通过应用工程科学来为管理和治疗失禁中存在的许多挑战提供新颖的解决方案，从而最大程度地提高和扩展当前印象网络的影响。与血管，心脏和骨科医疗保健等领域相比，在该领域缺乏科学研究 - 每种领域通过应用集中的基本和转化科学的应用显示出巨大的收益。FAECAL失禁（FI）被定义为无法完全控制粪便通过Anus的通过。这可能是由于肛门括约肌弱（通常是在儿童出生后），神经供应问题（例如中风，多发性硬化症）或与其他胃肠道疾病（例如肠易激综合征）相关的原因。这是一种常见且令人沮丧的状况，会导致羞耻，尴尬，沮丧，社会孤立，保密，自尊心和性避免。结果，超过54％的FI患者没有与医生讨论其症状，并且只有四分之一的FI患者被其GP转诊为专家治疗。它的确切患病率很难确定，但最佳估计表明，在成年人口中，它约为10％，低于65岁以下的0.5％ - 1％，而在65年中的3％ - 8％经历了常规的粪便失禁。尿失禁（UI）被定义为尿液的非自愿泄漏，UI给NHS资源带来了重大负担。这是一种常见且令人痛苦的状况，影响生活质量。 UI的主要形式是应力尿失禁（SUI），它是由于身体的努力而泄漏的，并敦促尿失禁（UUI），它是泄漏的，强烈渴望空白。混合的尿失禁是SUI和UUI的结合。 UI的患病率随着年龄的增长而增加，并且在制度化的成年人中较高，他们往往年龄较大并且遭受相关的合并症。对于女性来说，这通常是一个问题，女性的患病率在4.5％至53％之间，而男性为1.5％和24％。尽管以前是孤立的，但越来越多地认识到，许多形式的FI和UI具有共同的潜在病理生理学，并且经常与骨盆器官脱垂共存。不可能给NHS带来巨大的负担，并对英国成千上万患者的生活质量产生重大影响。尽管医学工程的许多领域在工程师和科学家的参与方面具有增长，以推动对新兴技术的开发，但可以说，这种疾病的本质可以阻止工程学和科学研究的领导者看到一些丰富的研究挑战的潜力。迄今为止，印象深刻的网络已经成功地实现了其增加了研究与尿失禁相关的临床变化研究的英国领先技术人员（来自学术界和行业）的目标。这是通过一系列令人兴奋的新合作项目来证明的，这些项目来自印象深刻的研讨会和活动，并得到了网络中竞争性的泵送资金的支持。 Impressplus将确保现有的Impress网络的遗产。这将通过以下方式通过：1）通过可行性项目资金在战略上支持新兴的研究2）运行国际Impressplus会议研讨会，以建立网络来建立网络3）使用研究人员的借调计划，以帮助行业和领先的国际研究基础进行知识转移4）将网络调查转移到研究人员，患者，医疗保健提供者和政策制造商中的长期研究，以确定网络的范围，并筹集到筹款活动。解决当前的僵局，以扼杀用于管理，治疗和预防尿失禁的新工程技术的创新和翻译。