STUDIES ON REPRODUCTIVE PHYSIOLOGY IN THE MACAQUE

猕猴生殖生理学的研究

• 批准号: 3485111
• 负责人: ERNST KNOBIL
• 金额: $ 18.8万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3485111
• 关键词: animal puberty; electrophysiology; estradiol; follicle stimulating hormone; hormone regulation /control mechanism; hypothalamus; lactation; luteinizing hormone; menstrual cycle; neural information processing; neuroendocrine system; ovariectomy; pregnancy; progesterone; radioimmunoassay; reproduction

This is the continuation of a research program of long standing, designed to elucidate the neuroendocrine control systems which govern reproductive processes in the rhesus monkey, a representative primate. Much of what is learned using this experimental model has been and continues to be applicable to the understanding of human reproductive physiology. During the next project period the functioning of the hypothalamic LHRH pulse generator will be studied in unrestrained females throughout the normal menstrual cycle, pregnancy, lactation and the advent of puberty. The influence of mild pertubations in the environment will also be investigated. Pulse generator activity will be assessed using electrophyciological techniques couples with radiotelemetry permitting continuous monitoring of this control system in freely behaving animals. In addition, the ongoing study of the influence of various ovarian factors, other than estradiol and progesterone, on the hypothalamic LHRH pulse generator will be continued.

这是一项长期研究计划的延续，旨在 阐明控制生殖的神经内分泌控制系统 恒河猴（灵长类动物的代表）的过程。 很多是什么 使用这个实验模型学到的知识已经并将继续 适用于理解人类生殖生理学。 期间 下一个项目期间下丘脑 LHRH 脉冲的功能 发电机将在整个正常的不受约束的女性中进行研究 月经周期、怀孕、哺乳和青春期的到来。 这 环境中轻微扰动的影响也会 调查了。 脉冲发生器活动将使用以下方式进行评估 电生理学技术与无线电遥测技术相结合 在自由行为的动物中连续监测该控制系统。 此外，正在进行的各种卵巢因素影响的研究， 除雌二醇和黄体酮外，下丘脑 LHRH 脉冲 发电机将继续。