STUDIES ON REPRODUCTIVE PHYSIOLOGY IN THE MACAQUE

猕猴生殖生理学的研究

• 批准号: 3314431
• 负责人: ERNST KNOBIL
• 金额: $ 12.72万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 1986-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3314431
• 关键词: adrenergic agents; animal puberty; corpus luteum; electrodes; electrophysiology; endocrine pharmacology; estrogens; experimental brain lesion; follicle stimulating hormone; hormone regulation /control mechanism; lactation; luteinizing hormone; median eminence; menstrual cycle; neural information processing; neuroendocrine system; opiate alkaloid; oral behavior; ovariectomy; ovulation; pituitary gonadal axis; pregnancy; progesterone; prolactin; radioimmunoassay; secretion; stereotaxic techniques; tissue /cell culture

The broad and long-term objective of this ongoing research program is to elucidate the neuroendocrine control systems which govern reproductive processes in a representative primate, the rhesus monkey. The principal thrust of this investigation is to characterize the hypothalamic pulse generator which governs the circhoral discharges of the gonadotropic hormones congruent to the release of GnRH into the pituitary portal circulation. As a first step, the description of the electrophysiological correlates of pulsatile gonadotropin release and their source(s) will be completed. The modulation of this electrophysiological activity by gonadal hormones and pharmacological agents known to modify gonadotropin secretion will then be studied to determine the possible role of pulse generator activity in the mode of action of these agents. Lastly, the electrophysiological activity of the pulse generator in physiologic as well as pathophysiologic contexts will be investigated using telemetry of signals from chronically implanted hypothalamic recording electrodes. These studies will include the normal menstrual cycle, pregnancy and parturition, the influence of suckling and the advent of puberty. The effects of mild restraint and the introduction of cardiac catheters previously shown to interfere with normal hypophysial-ovarian function will also be examined.

这项正在进行的研究计划的广泛和长期目标是 阐明控制生殖的神经内分泌控制系统 代表性灵长类动物恒河猴的过程。 校长 这项研究的主旨是表征下丘脑脉冲 控制促性腺激素循环放电的发生器 与 GnRH 释放到垂体门一致的激素 循环。 第一步，描述电生理学 脉冲性促性腺激素释放的相关性及其来源将是 完全的。 性腺对这种电生理活动的调节 已知可改变促性腺激素分泌的激素和药物 然后将进行研究以确定脉冲发生器的可能作用 这些药物的作用方式中的活性。 最后， 脉冲发生器在生理学中的电生理活动 因为病理生理学背景将使用遥测技术进行研究 来自长期植入的下丘脑记录电极的信号。 这些研究将包括正常的月经周期、怀孕和 分娩、哺乳的影响和青春期的到来。 这 轻度约束和引入心导管的效果 先前显示会干扰正常的垂体卵巢功能 也予以检查。