Development and optimisation of downstream processing for next generation biotherapeutics

下一代生物治疗药物下游加工的开发和优化

• 批准号: EP/N013395/1
• 负责人: Daniel Bracewell
• 金额: $ 46.28万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN013395%2F1
• 关键词: Development; optimisation; downstream; processing; next

In recent years there has been rapid development of a "Next Generation" of protein-based therapeutics, yet the need remains for new manufacturing processes that can deliver these at a price healthcare providers can afford. For the first time these new therapies can safely modify a patient's DNA, or harness the body's own immune system, to treat inherited diseases, neurological conditions, and cancer. However, to achieve this clinical functionality the complexity and size of the therapeutic protein has increased. This has meant that existing purification technologies have been unable to be applied effectively in this new application. This project aims to build on existing collaborations and feasibility data to develop new purification tools and strategies that can be applied across a range of next generation biotherapeutics to enable their cost effective manufacture delivering novel therapies to patients at an aceeptable price for healthcare payers.

近年来，“下一代”的基于蛋白质的治疗剂的发展迅速，但是对于可以在价格医疗保健提供者可以承受的新制造过程中仍然需要提供这些工艺的需求。这些新疗法首次可以安全地修改患者的DNA，或利用人体自身的免疫系统治疗遗传性疾病，神经系统疾病和癌症。但是，为了达到这种临床功能，治疗蛋白的复杂性和大小已增加。这意味着现有的纯化技术无法在此新应用程序中有效应用。该项目旨在建立现有的合作和可行性数据，以开发新的纯化工具和策略，这些工具和策略可在下一代生物治疗学上应用，以使其具有成本效益的生产，以可与医疗保健付款人的可观价格为患者提供新的疗法。

项目成果

Cover Image, Volume 116, Number 7, July 2019

封面图片，第 116 卷，第 7 号，2019 年 7 月

• DOI: 10.1002/bit.26760
• 发表时间: 2019
• 期刊: Biotechnology and Bioengineering
• 影响因子: 3.8
• 作者: Turnbull J

Adenovirus 5 recovery using nanofiber ion-exchange adsorbents.

使用纳米纤维离子交换吸附剂回收腺病毒 5。

• DOI: 10.1002/bit.26972
• 发表时间: 2019
• 期刊: Biotechnology and bioengineering
• 影响因子: 3.8
• 作者: Turnbull J

Lentiviral Vector Purification Using Nanofiber Ion-Exchange Chromatography.

使用纳米纤维离子交换色谱法纯化慢病毒载体。

• DOI: 10.1016/j.omtm.2019.08.007
• 发表时间: 2019
• 期刊: Molecular therapy. Methods & clinical development
• 作者: Ruscic J