Continuous Chemical Manufacture with Light (C2ML)

光连续化学制造 (C2ML)

• 批准号: EP/L021889/1
• 负责人: Martyn Poliakoff
• 金额: $ 37.47万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FL021889%2F1
• 关键词: Continuous; Chemical; Manufacture; Light; C2ML

The manufacture of chemicals makes a major contribution to the UK's economy; £10 bn p.a. in the chemicals and £9bn in the pharmaceuticals sectors alone. The recent report of the Chemistry Growth Strategy Group states that 'By 2030, the UK chemical industry will have further reinforced its position as the country's leading manufacturing exporter and enabled the chemistry-using industries to increase their Gross Value Added contribution to the UK economy by 50%' with "smart manufacturing" as one of three priorities in realising their vision. Our proposal aims to contribute to this smart manufacturing by transforming the way in which continuous photochemistry can be applied to commercial chemical manufacture. There is considerable current academic interest in new photochemical reactions for organic synthesis but how they might be used industrially is usually ignored. Nevertheless the potential of photochemistry in manufacturing is widely recognized if only it could be made scalable and efficient. Traditionally the pharmaceutical and fine chemicals industries have used batch reactors for manufacture, which are difficult to adapt effectively for photochemistry. Therefore, this proposal focuses on continuous reactors which not only permit innovation in design to overcome technical limitations of current photoreactors but also provide a direct route to increased throughput via scale up or scale out.We will tackle some of the technical and engineering issues inherent in conventional photoreactors. These engineering problems include getting light efficiently into the reactors, build-up of opaque material on transparent surfaces key safety issues, particularly in reactions involving oxidation, as well as cost issues related to low efficiency of many light sources and difficulties of scale up. Our project proposes to create new engineering approaches to continuous photochemical manufacture of chemicals, which could transform chemical processes and cost. Our proposal addresses key technical/scientific barriers frustrating current commercial use of photochemistry and promises cheaper products in the pharmaceutical, agrochemical and fine chemicals sectors. Our team consists of three investigators with a proven track record of taking chemical processes from laboratory to commercial plant. Between us, we have the expertise needed for success; namely, in photochemistry, continuous organic reactions, manufacturing, mechanical and chemical engineering and process monitoring.

化学品制造对英国经济做出了重大贡献；化学品行业每年贡献 100 亿英镑，制药行业贡献 90 亿英镑。化学增长战略小组最近的报告指出，“到 2030 年，英国化学工业将达到 90 亿英镑”。进一步巩固了其作为英国领先制造业出口国的地位，使化学工业对英国经济的总增加值贡献增加了50%”，其中“智能制造”是实现这一目标的三大优先事项之一他们的愿景是通过改变连续光化学应用于商业化学制造的方式来为智能制造做出贡献。目前学术界对有机合成的新光化学反应有很大兴趣，但它们如何在工业上使用通常是未知数。然而，光化学在制造中的潜力已得到广泛认可，只要它能够实现可扩展和高效。传统上，制药和精细化学品行业使用间歇式反应器进行制造，这很难有效地适应光化学。连续反应器不仅允许设计创新以克服当前光反应器的技术限制，而且还提供通过放大或缩小来增加吞吐量的直接途径。我们将解决传统光反应器固有的一些技术和工程问题，这些工程问题包括。将光有效地引入反应器、在透明表面上形成不透明材料是关键的安全问题，特别是在涉及氧化的反应中，以及与许多光源的低效率和扩大规模的困难相关的成本问题。新的工程方法我们的提案解决了目前阻碍光化学商业应用的关键技术/科学障碍，并有望在制药、农用化学品和精细化学品领域提供更便宜的产品。我们拥有将化学工艺从实验室转化为商业工厂的良好记录，拥有成功所需的专业知识；即光化学、连续有机反应、制造、机械和化学工程以及过程监控。

项目成果

Photocatalytic hydroxylation of arylboronic acids using continuous flow reactors

使用连续流动反应器进行芳基硼酸的光催化羟基化

• DOI: 10.1039/c4ra15588b
• 发表时间: 2024-09-13
• 期刊: RSC Advances
• 影响因子: 3.9
• 作者: Inès G. T. M. Penders;Zacharias Amara;Raphael Horvath;K. Rossen;M. Poliakoff;M. George
• 通讯作者: M. George

Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory.

涡旋反应器中的连续光氧化：使用从实验室抽取的空气进行高效操作。

• DOI: http://dx.10.1021/acs.oprd.7b00153
• 发表时间: 2017
• 期刊: Organic process research & development
• 影响因子: 3.4
• 作者: Lee DS

Applying green chemistry to the photochemical route to artemisinin.

将绿色化学应用于青蒿素的光化学路线。

• DOI: 10.1038/nchem.2261
• 发表时间: 2015-06-01
• 期刊: Nature chemistry
• 影响因子: 21.8
• 作者: Zacharias Amara;Jessica F. B. Bellamy;Raphael Horvath;Samuel J. Miller;A. Beeby;A. Burgard;K. Rossen;M. Poliakoff;M. George
• 通讯作者: M. George

A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation

实验室规模的用于紫外光化学的环形连续流反应器，使用准分子灯进行离散波长激发及其在光脱羧环化的波长研究中的应用

• DOI: http://dx.10.1039/c6gc02888h
• 发表时间: 2017
• 期刊: Green Chemistry
• 影响因子: 9.8
• 作者: DeLaney E

A Simple and Versatile Reactor for Photochemistry

简单而多功能的光化学反应器

• DOI: 10.1021/acs.oprd.6b00257
• 发表时间: 2016-09-21
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Charlotte A. Clark;Darren S. Lee;S. Pickering;M. Poliakoff;M. George
• 通讯作者: M. George