Experimental Equipment Call - University of Leeds

实验设备调用 - 利兹大学

• 批准号: EP/M028143/1
• 负责人: David Hogg
• 金额: $ 469.65万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM028143%2F1
• 关键词: Experimental; Equipment; Call; University; Leeds

The objective of this proposal is to refresh and update key items of experimental equipment in activities aligned to proven strengths and critical mass in Medical Engineering and Advanced Materials at the University of Leeds.The Institute of Medical and Biological Engineering hosts the largest and most advanced musculoskeletal simulation facility in the world. The new simulators will support three of our strategic research challenges: longer lasting joint replacements; regenerative devices and biological scaffolds for tissue repair; and, advanced simulation systems for virtual analysis and design and preclinical testing. They will deliver enhanced functionality, allowing the development and introduction of SAFER (Stratified Approaches For Enhanced Reliability) simulation methods to address the requirements of stratified and personalized medical devices, biomaterials and scaffolds. The simulators will be used for research into the tribology and wear of artificial joints, validation of novel computational methods for prediction of function, studies of wear debris and supporting biocompatibility research and studies of the tribology of biological scaffolds in natural joints, using recently developed methods.Our research in terahertz (THz) frequency electronics and photonics is internationally leading by any criterion. Much of this activity requires a state-of-the-art and dedicated MBE semiconductor growth system. The new MBE system will allow us to protect the UK's international reputation in this field and, in particular, in the growth and exploitation of THz frequency quantum cascade lasers (QCLs). Over the next five years we will: develop state-of-the-art THz QCLs across the 1-5 THz range, maximizing operating temperature, continuous-wave performance, output power, and gain bandwidth; develop THz QCLs engineered into robust device architectures for use as, for example, local oscillators in earth-observation and planetary science missions; develop compact bench-top QCL-based technologies producing intense, narrowband and precisely controllable pulses for non-linear THz science; and, develop self-organised quantum rod structures for cavity-QED experiments, and new optically-pumped, vertical-cavity surface-emitting room temperature THz lasers.The Leeds Electron Microscopy and Spectroscopy (LEMAS) Centre is a highly successful shared electron microscopy facility. It has high visibility nationally (providing an EPSRC open access scheme for external users since 2008) and internationally (leading the consortium that formed the UK facility at SuperSTEM Daresbury). One of the next great challenges is apply high-resolution imaging and microanalytical techniques to beam sensitive materials, including advanced hybrid materials comprising organic and inorganic components. These are increasingly employed to develop new device and product functionalities. The specification of the new microscope is unique and designed to enable fast mapping of frozen specimens at high accelerating voltage to preserve their chemistry and structure whilst extracting nanostructural information.We are internationally recognised in spintronics and magnetic materials, with recent appointments extending our materials expertise to include organic molecules, piezoelectrics, topological insulators and superconductors. The new deposition tool will ensure we can continue to supply top quality thin film materials to the UK and internationally, as well as underpinning a general theme of spintronic meta-materials. The functional properties of meta-materials emerge through the design and engineering of the constituent material combinations. With our broad background that includes the ability to structure materials at the nanoscale so that cooperative behaviour arises, we will apply this capability to questions in strategic areas such as quantum effects for new technology, beyond CMOS electronics, energy efficient electronics, and new tools for healthcare.

该提案的目的是在LEED大学的医学工程和高级材料中刷新和更新实验设备的关键项目。新的模拟器将支持我们的三个战略研究挑战：更长的持久关节替代品；用于组织修复的再生装置和生物支架；以及用于虚拟分析和设计以及临床前测试的高级仿真系统。他们将提供增强的功能，从而开发和引入更安全的（增强可靠性的分层方法）模拟方法，以解决分层和个性化的医疗设备，生物材料和脚手架的要求。模拟器将用于研究人造关节的摩擦学和磨损，对功能预测的新型计算方法的验证，磨损碎片的研究以及使用最近开发的自然关节生物支架摩擦学研究的研究，并使用最近开发的方法研究。这项活动的大部分都需要最先进和专用的MBE半导体增长系统。新的MBE系统将使我们能够保护英国在该领域的国际声誉，尤其是在THZ频率量子级联激光器（QCLS）的增长和开发中。在接下来的五年中，我们将：在1-5 THZ范围内开发最新的THZ QCL，最大化工作温度，连续波性能，输出功率和增益带宽；开发QCLS设计为强大的设备体系结构，以便使用地球观察和行星科学任务中的本地振荡器；开发基于QCL的紧凑型基于QCL的技术，可为非线性THZ科学产生强烈的，窄带和精确控制的脉冲；并且，开发自组织的量子杆结构，用于腔QED实验，以及新的光泵，垂直腔表面发射室温THZ激光器。LEEDS电子显微镜和光谱（LEMAS）中心是一个非常成功的共享电子显微镜设施。它在全国范围内具有很高的知名度（自2008年以来为外部用户提供EPSRC开放访问计划）和国际（领导了在Superstem Daesbury组成英国工厂的财团）。下一个巨大的挑战之一是将高分辨率成像和微分析技术应用于光束敏感材料，包括包括有机和无机组件的先进杂交材料。这些越来越多地用于开发新的设备和产品功能。 The specification of the new microscope is unique and designed to enable fast mapping of frozen specimens at high accelerating voltage to preserve their chemistry and structure whilst extracting nanostructural information.We are internationally recognised in spintronics and magnetic materials, with recent appointments extending our materials expertise to include organic molecules, piezoelectrics, topological insulators and superconductors.新的沉积工具将确保我们可以继续向英国和国际上提供高质量的薄膜材料，并以旋转元材料的一般主题为基础。元物质的功能性能通过组成材料组合的设计和工程出现。我们的广泛背景包括在纳米级上构造材料的能力，以便出现合作行为，我们将把这种能力应用于战略领域的问题，例如新技术的量子效应，除了CMOS电子设备，节能电子设备以及医疗保健新工具。

项目成果

The influence of simulator input conditions on the wear of total knee replacements: An experimental and computational study.

• DOI: 10.1177/0954411916645134
• 发表时间: 2016-05
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Brockett CL;Abdelgaied A;Haythornthwaite T;Hardaker C;Fisher J;Jennings LM
• 通讯作者: Jennings LM

Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings.

• DOI: 10.1177/0954411915620454
• 发表时间: 2016-05
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Ali M;Al-Hajjar M;Partridge S;Williams S;Fisher J;Jennings LM
• 通讯作者: Jennings LM

Simple geometry tribological study of osteochondral graft implantation in the knee.

• DOI: 10.1177/0954411917751560
• 发表时间: 2018-03
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Bowland P;Ingham E;Fisher J;Jennings LM
• 通讯作者: Jennings LM

Influence of conformity on the wear of total knee replacement: An experimental study.

• DOI: 10.1177/0954411917746433
• 发表时间: 2018-03
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Brockett CL;Carbone S;Fisher J;Jennings LM
• 通讯作者: Jennings LM

PEEK and CFR-PEEK as alternative bearing materials to UHMWPE in a fixed bearing total knee replacement: An experimental wear study.

• DOI: 10.1016/j.wear.2016.12.010
• 发表时间: 2017-03-15
• 期刊: Wear : an international journal on the science and technology of friction lubrication and wear
• 作者: Brockett CL;Carbone S;Fisher J;Jennings LM
• 通讯作者: Jennings LM