Bridging the Gaps: Systems-level approaches to antimicrobial resistance

弥合差距：解决抗菌素耐药性的系统级方法

基本信息

批准号：
EP/M027333/1
负责人：
John King
金额：
$ 62.59万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM027333%2F1
关键词：
Bridging Gaps Systems level approaches

项目摘要

The problem of antimicrobial resistance (AMR) is an increasing challenge, not only in the context of healthcare but also in, for example, food safety and agriculture. The prevalence of resistant bugs such as MRSA has received widespread media coverage and the problems relating to resistance are now more widely recognised than ever before, as is the importance of developing new approaches, particularly given the increase in issues associated with multidrug resistant species. The current proposal seeks to drawn on wide-ranging applicable expertise in engineering and the physical sciences that, in collaboration with biological-science researchers, clinicians and industry, offers hitherto unexploited opportunities to contribute significantly to addressing these very significant challenges.We shall accordingly deliver a programme of activities that promotes new interdisciplinary collaborations across traditional boundaries between engineering, the physical sciences and the biological sciences. The University of Nottingham has an outstanding history of such discipline-bridging activities, as well as of research relevant to AMR, and will bring this experience to bear upon the challenge of AMR. The primary mechanism for promoting new research collaborations will be that of themed Sandpits, building on the success of the Mathematics-in-Medicine Study Groups pioneered by the University in 2000 (and subsequently spawning the Mathematics-in-the-Plant-Sciences Study Groups and others). In these, presenters from the biological sciences, clinical medicine or industry will describe issues that could benefit from new approaches drawn from engineering and the physical sciences; intensive brain-storming work on these topics will identify the skills needed and establish the relevant cross-disciplinary teams; seed funding will then be provided for the most promising projects identified. While the process is now well-established, the outcomes of such workshops are very far from predictable and the aggregation of the range of disciplines outlined above should ensure that innovative approaches come to the fore. Other mechanisms will include Challenge Days (modifying the successful approach of the Industry Challenge Days held by the Business School to ensure that research developments align with the needs of potential end users), discipline-hopping secondments, speed-networking sessions, cross-disciplinary workshops (focussing on specific methodologies, to enhance further the opportunities for identifying potential crossovers between research fields) and annual showcases in the form of a launch event and a concluding 'forward-look' workshop. These activities will be augmented by a Visiting-Scholar programme whereby leading experts in complementary areas will contribute their expertise to the initiative.Funding from the programme will be assigned in competition to multidisciplinary projects judged on their research excellence and their capacity to contribute to addressing AMR challenges. The programme's Strategy Group will be responsible for assessing applications and for monitoring progress; the activities outlined above are specifically designed (in particular by bringing together researchers from diverse disciplines) to ensure that the research ideas developed are highly innovative and that the associated projects have the required mix of research expertise. The programme will be very explicitly outward-facing, drawing extensively on input from clinicians, industrialists and other potential end users, as well as interacting with complementary research elsewhere. In combination with the excellence and innovation of the research developed, such collaborations will ensure the sustainability of the initiative.

抗菌素耐药性（AMR）的问题不仅在医疗保健方面，而且在例如食品安全和农业的背景下是一个日益严重的挑战。 MRSA等抗性错误的流行率已获得广泛的媒体覆盖范围，并且与抵抗有关的问题比以往任何时候都更加广泛地认识，而开发新方法的重要性也是如此，尤其是考虑到与多种耐药物种相关的问题的增加。当前的提案旨在利用广泛的工程专业知识以及与生物学科学研究人员，临床医生和行业合作提供的物理科学专业知识，为迄今为止尚未开发的机会，可以为解决这些非常重要的挑战做出重要贡献。我们将相应地提供跨学科的跨学科活动的活动计划，以促进跨学科的跨学科范围。诺丁汉大学在此类学科的桥梁活动以及与AMR相关的研究方面拥有杰出的历史，并将带来这种经验，以应对AMR的挑战。促进新研究合作的主要机制将是主题砂把的基础，该机制是基于该大学在2000年开创的中医学研究小组的成功（随后催生了数学研究小组和其他研究小组等）。在这些过程中，来自生物科学的演示者，临床医学或行业将描述可能受益于工程学和物理科学的新方法的问题；在这些主题上进行密集的大脑宣传工作将确定所需的技能，并建立相关的跨学科团队；然后，将为确定的最有前途的项目提供种子资金。尽管该过程现在已经建立了良好，但此类研讨会的结果远非可预测的，并且上面概述的一系列学科范围的汇总应确保创新方法浮出水面。 Other mechanisms will include Challenge Days (modifying the successful approach of the Industry Challenge Days held by the Business School to ensure that research developments align with the needs of potential end users), discipline-hopping secondments, speed-networking sessions, cross-disciplinary workshops (focussing on specific methodologies, to enhance further the opportunities for identifying potential crossovers between research fields) and annual showcases in the form of a launch event and a concluding 'forward-look'车间。这些活动将通过一项访问策略计划来增强，在该计划中，互补领域的领先专家将为该计划提供贡献。从该计划中获得的资金将分配给对卓越研究的多学科项目，并根据其卓越的研究能力及其为应对AMR挑战做出贡献的能力。该计划的战略组将负责评估申请和监视进度；上面概述的活动是专门设计的（特别是通过将来自不同学科的研究人员汇集在一起），以确保开发的研究思想具有很高的创新性，并且相关的项目具有研究专业知识所需的组合。该计划将非常明确地向外，从而广泛利用临床医生，工业家和其他潜在最终用户的意见，并与其他地方的补充研究互动。结合了开发的研究的卓越和创新，此类合作将确保该计划的可持续性。