FUNCTIONAL REGRESSION IN MENTALLY RETARDED ADULTS

成人弱智的功能退化

• 批准号: 3469844
• 负责人: WARREN B ZIGMAN
• 金额: $ 10.15万
• 依托单位: INSTITUTE FOR BASIC RES IN DEV DISABIL
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3469844
• 关键词: Alzheimer's disease; Downs syndrome; aging; behavior disorders; disease /disorder proneness /risk; human subject; human tissue; longitudinal human study; medical records; mental retardation; nervous system disorder diagnosis; postmortem; psychometrics; psychomotor disorders

Recent improvements in medical care have markedly increased the life span of individuals with Down syndrome, and many older people with Down syndrome exhibit changes in health and functional capacities suggestive of premature or accelerated aging. Indeed, there is strong evidence that there is in this population a unique susceptibility to Alzheimer's disease. However, existing studies of the association between Down syndrome and Alzheimer's disease have been limited with respect to their design, sample size, and subject selection criteria. The present investigation will collect longitudinal data regarding age-related changes in adaptive behavior in a large group of middle aged to older people with Down syndrome, and compare them to a matched group without Down syndrome. Matching variables will be age, sex, residential placement, and severity of mental retardation. Adaptive behavior will be assessed using the A.A.M.D. Adaptive Behavior Scale, a standardized and reliable instrument. The largest and most representative sample of older people with Down syndrome will be studied, and the most accurate data on the aging in mentally retarded individuals collected to date will be provided. If, as we expect, people with Down syndrome do regress in functioning as they age, results of this study will be used to describe the progression of symptoms. Additionally, because a high rate of autopsy among study participants who die is anticipated, a determination of the relationship between the extent of regression in adaptive behavior and neuropathological changes diagnostic of Alzheimer's disease will be made.

医疗服务的最新改善已明显增加 唐氏综合症的个体的寿命，许多年龄较大 患有唐氏综合症的人的健康状况变化 功能能力提示过早或加速 老化。 确实，有强有力的证据表明这有 人口对阿尔茨海默氏病的独特敏感性。 但是，现有关于降低之间关联的研究 综合征和阿尔茨海默氏病受到限制 符合其设计，样本量和主题选择标准。 本调查将收集有关的纵向数据 一大批自适应行为与年龄相关的变化 中年是唐氏综合症的老年人，并比较 他们参加没有唐氏综合症的匹配组。 匹配 变量将是年龄，性别，住宅位置和严重性 智力低下。 自适应行为将使用 A.A.M.D.自适应行为量表，标准化和可靠 乐器。 老年人最大，最具代表性的样本 将研究患有唐氏综合症的人，最多 精神智障人士衰老的准确数据 迄今为止将提供收集。 如果正如我们期望的那样，患有唐氏综合症的人会退缩 随着年龄的增长，本研究的结果将用于 描述症状的进展。 另外，因为 死亡的研究参与者之间的高尸检是 预期的是，确定 自适应行为和神经病理学的回归程度 将对阿尔茨海默氏病的诊断变化。