NMDA RECEPTOR EXPRESSION IN AGING AND ALZHEIMER'S

NMDA 受体在衰老和阿尔茨海默病中的表达

• 批准号: 6539220
• 负责人: Daniel A Clayton
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-09 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6539220
• 关键词: Alzheimer's disease; Downs syndrome; NMDA receptors; aging; clinical research; disease /disorder model; laboratory mouse; laboratory rat; postmortem; psychopharmacologic agent; psychopharmacology; receptor expression

DESCRIPTION: (Verbatim from the Applicant's Abstract) The hippocampus has been implicated as a crucial region in learning and memory, and damage to the hippocampus or its associated neuronal circuitry has been described in both age-related and Alzheimer's type dementia. The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is thought to be critical to the fundamental functioning of the hippocampus. Recently we have developed antibodies and other molecular probes to NMDA receptor subunits which h will allow us to characterized the expression patterns of NMDA receptor subunits in both animal models of aging and Alzheimer's disease (AD) and in human post-mortem tissue from aged individuals and those with AD. In addition we will examine the role of transcriptional regulation of the NMDA receptor subunits as it relates to any differences seen in expression. In order to examine the importance of any changes which are found, we will examine the patterns of expression of NMDA receptor subunits in treatment paradigms which have been shown to ameliorate behavioral aspects of age-related and Alzheimer's type dementia. An understanding of the role of NMDA receptor in the pathogenesis of age-related and Alzheimer's type dementia could further our understanding of the underlying pathology of these disorders and may suggest new therapeutic approaches.

描述：（逐字研究申请人的摘要）海马已经 在学习和记忆中被视为至关重要的地区，并损害了 海马或其相关的神经元电路已经描述 与年龄相关的和阿尔茨海默氏症的型痴呆症。 N-甲基-D-天冬氨酸（NMDA） 谷氨酸受体的亚型被认为对基本至关重要 海马的功能。最近我们开发了抗体和其他 NMDA受体亚基的分子探针将使我们能够 表征了两种动物中NMDA受体亚基的表达模式 衰老和阿尔茨海默氏病（AD）和人类后组织的模型 来自老年人和有广告的人。此外，我们将检查角色 NMDA受体亚基的转录调节 表达中看到的任何差异。为了检查任何的重要性 发现的变化，我们将检查NMDA表达的模式 在治疗范例中的受体亚基已显示为改善 与年龄相关的行为方面和阿尔茨海默氏症型痴呆症。 了解NMDA受体在发病机理中的作用 与年龄相关的和阿尔茨海默氏症类型的痴呆症可以进一步了解我们对 这些疾病的基本病理，可能暗示新的治疗性 方法。