NMDA RECEPTOR EXPRESSION IN AGING AND ALZHEIMER'S

NMDA 受体在衰老和阿尔茨海默病中的表达

• 批准号: 6539220
• 负责人: Daniel A Clayton
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-09 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6539220
• 关键词: Alzheimer's disease; Downs syndrome; NMDA receptors; aging; clinical research; disease /disorder model; laboratory mouse; laboratory rat; postmortem; psychopharmacologic agent; psychopharmacology; receptor expression

DESCRIPTION: (Verbatim from the Applicant's Abstract) The hippocampus has been implicated as a crucial region in learning and memory, and damage to the hippocampus or its associated neuronal circuitry has been described in both age-related and Alzheimer's type dementia. The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is thought to be critical to the fundamental functioning of the hippocampus. Recently we have developed antibodies and other molecular probes to NMDA receptor subunits which h will allow us to characterized the expression patterns of NMDA receptor subunits in both animal models of aging and Alzheimer's disease (AD) and in human post-mortem tissue from aged individuals and those with AD. In addition we will examine the role of transcriptional regulation of the NMDA receptor subunits as it relates to any differences seen in expression. In order to examine the importance of any changes which are found, we will examine the patterns of expression of NMDA receptor subunits in treatment paradigms which have been shown to ameliorate behavioral aspects of age-related and Alzheimer's type dementia. An understanding of the role of NMDA receptor in the pathogenesis of age-related and Alzheimer's type dementia could further our understanding of the underlying pathology of these disorders and may suggest new therapeutic approaches.

描述：（逐字摘自申请人摘要）海马体已被 涉及学习和记忆的关键区域，以及对 海马体或其相关的神经元回路已在两篇文章中进行了描述 与年龄相关的痴呆症和阿尔茨海默氏症型痴呆症。 N-甲基-D-天冬氨酸 (NMDA) 谷氨酸受体亚型被认为对于基本功能至关重要 海马体的功能。最近我们开发了抗体和其他 NMDA 受体亚基的分子探针 h 将使我们能够 表征了两种动物中 NMDA 受体亚基的表达模式 衰老和阿尔茨海默病 (AD) 模型以及人类死后组织 来自老年人和 AD 患者。此外，我们还将研究角色 NMDA 受体亚基的转录调控 表达中看到的任何差异。为了检验任何一项的重要性 发现变化后，我们将检查 NMDA 的表达模式 治疗范例中的受体亚基已被证明可以改善 年龄相关性痴呆和阿尔茨海默氏型痴呆的行为方面。 了解 NMDA 受体在疾病发病机制中的作用 与年龄相关的痴呆症和阿尔茨海默氏症型痴呆症可以进一步加深我们对 这些疾病的潜在病理学并可能提出新的治疗方法 接近。