High resolution, multi-material deposition of tissue engineering scaffolds

组织工程支架的高分辨率、多材料沉积

• 批准号: EP/M018989/1
• 负责人: Yan Huang
• 金额: $ 12.66万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM018989%2F1
• 关键词: resolution; multi; material; deposition; tissue

The next generational change in health treatment will be the tailoring of artificial implants in combination with a patient's own cells to replace diseased or damaged tissues and organs. There will also be development in drug research through the creation of complex tissue models in vitro that mimic certain body systems. With these models we will be able to reduce the need for animal testing and provide a deeper understanding of the impact of drugs on cell function. To undertake these changes, one requires a fabrication technique that can accommodate a wider choice of biomaterials, combined with delivery of complexity in terms of feature size, structure and functionalities. This project aims to develop a new biomaterial fabrication technique which can process different material elements into a sizable scaffold in a controllable, scalable manner. The configuration will be tailored to fit the ultimate reaction kinetics of the biomaterial. This technique will exhibit (a) a sub-micron printing resolution of fibrous structures (vs. tens of micron of the existing 3-D printing), (b) ability to co-print both fibrous components and interstitial gel components, (c) suitability for scaled-up fabrication of a vast biomaterial library without needing to modify the native material chemistry. Ultimately, this new biomaterial fabrication technique will enable the reproducible, automated creation of multi-functional biomaterial scaffolds to support soft tissue regeneration. It is believed that the proposed technique will facilitate the fabrication of personalised scaffold parts, thus enabling more effective treatment available to the general public.

健康治疗的下一个世代变化将是与患者自己的细胞结合使用人造植入物来替代患病或受损的组织和器官。通过在模仿某些身体系统的体外创建复杂的组织模型，在药物研究中也将有发展。通过这些模型，我们将能够减少对动物测试的需求，并对药物对细胞功能的影响有更深入的了解。为了进行这些变化，需要一种制造技术，可以适应更广泛的生物材料，并结合特征大小，结构和功能的复杂性。该项目旨在开发一种新的生物材料制造技术，该技术可以以可控制的，可扩展的方式将不同的材料元素处理为相当的脚手架。该构型将量身定制，以适合生物材料的最终反应动力学。该技术将展示（a）纤维结构的亚微米打印分辨率（与现有3-D打印的数十微米相比），（b）具有纤维成分和间质凝胶成分的能力，（c）适用于扩大庞大生物材料文库的规模制造，而无需修改天然材料化学。最终，这种新的生物材料制造技术将使多功能生物材料支架的可重复，自动化创建以支持软组织再生。据信，提出的技术将促进制造个性化的脚手架零件，从而为公众提供更有效的治疗方法。

项目成果

Bioprinting of three-dimensional culture models and organ-on-a-chip systems

三维培养模型和器官芯片系统的生物打印

• DOI: 10.17863/cam.13352
• 发表时间: 2017
• 作者: Huang Y

Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.

• DOI: 10.1038/s41598-018-30776-0
• 发表时间: 2018-08-20
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Bertulli C;Gerigk M;Piano N;Liu Y;Zhang D;Müller T;Knowles TJ;Huang YYS
• 通讯作者: Huang YYS

Additive batch electrospinning patterning of tethered gelatin hydrogel fibres with swelling-induced fibre curling

• DOI: 10.1016/j.addma.2020.101456
• 发表时间: 2020-12-01
• 期刊: ADDITIVE MANUFACTURING
• 影响因子: 11
• 作者: Gill, Elisabeth L.;Wang, Wenyu;Huang, Yan Yan Shery
• 通讯作者: Huang, Yan Yan Shery