OPTIMIZING PROTON THERAPY AT THE LBL MEDICAL ACCELERATOR

优化 LBL 医疗加速器的质子治疗

• 批准号: 3443673
• 负责人: JOSE ALONSO
• 金额: $ 57.64万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3443673
• 关键词: biomagnetism measurement; building /facility design /renovation; clinical biomedical equipment; linear energy transfer; particle accelerators; proton beam; radiation therapy; radiation therapy dosage; radiobiology

LBL is proposing the construction of a dedicated biomedical center for intensive development of heavy charged-particle techniques for clinical use. We anticipate the construction to start within the next five years. This center will emphasize research with both protons and heavier ions. The rationale of a strong proton component of our program lies with intercomparison of low and high LET irradiations, and technology transfer of hardware and techniques developed for hospital-based clinical proton facilities to be built worldwide in the near future. Specifically we will: (1) Study the technical elements needed for designing an integrated, efficient, reliable and cost-effective proton treatment facility. Optimize accelerator designs, beam spreading techniques, gantries, control systems, and systems-integration. Analyze applicability of new ideas (e.g. rapid- pulsing systems) and emerging technologies (e.g. superconductivity). (2) Investigate ways to utilize the best characteristics of proton beams for treatment of human diseases. Study 3-D conformal treatment techniques, their expected clinical benefits, interfacing treatment plans with beam delivery system, and the merits of correlating multiple imaging modalities. Using the particle beams from the Vevalac and the LBL dynamic beam delivery system, assess the performance of a 3-dimensional conformal therapy delivery system. (3) Identify disease sites that would most benefit from proton therapy and develop protocols for these sites. Identify areas where radiobiological input is critical for aid in interpretation of clinical results. Select protocols for which equitable intercomparison can be made of the clinical benefits of protons (low LEt) and heavier ions (high LET). The results of the project will provide timely input to the scientific and medical community which is witnessing a significant transfer of advanced technology of heavy charged-particle medicine from research institutions into the clinical environment.

LBL提议建设专门的生物医学中心 临床重型电荷粒子技术的密集开发 使用。 我们预计该建设将在未来五年内开始。 该中心将强调质子和较重离子的研究。 我们程序的强大质子组成部分的理由在于 低和高的辐射和技术转移的比较 为基于医院的临床质子开发的硬件和技术 在不久的将来将在全球建造的设施。 具体我们将： （1）研究设计集成的， 有效，可靠和具有成本效益的质子治疗设施。 优化 加速器设计，光束蔓延技术，龙头，控制系统， 和系统整合。 分析新想法的适用性（例如 脉冲系统）和新兴技术（例如超导性）。 （2） 调查利用质子梁最佳特征的方法 治疗人类疾病。 研究3-D共形治疗技术， 他们预期的临床益处，将治疗计划与光束接触 输送系统，以及将多个成像方式相关联的优点。 使用来自Vevalac和LBL动态束输送的粒子梁 系统，评估三维形式治疗的性能 交付系统。 （3）确定最能从中受益的疾病部位 质子治疗并为这些地点开发方案。 确定位置 放射生物学输入对于辅助解释临床至关重要 结果。 选择可以进行公平比较的协议 质子（低LET）和较重离子（高LET）的临床益处。 该项目的结果将及时为科学和 目睹高级转移的医学界 研究机构重型充电式药物的技术 进入临床环境。