PRENATAL ALCOHOL EXPOSURE--EFFECTS ON NEUROPLASTICITY

产前酒精暴露——对神经可塑性的影响

• 批准号: 3445138
• 负责人: ZEHAVA GOTTESFELD
• 金额: $ 4.87万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3445138
• 关键词: alcoholic beverage consumption; axon; blood chemistry; catechol methyltransferase; central nervous system disorders; experimental brain lesion; fetal alcohol syndrome; fluorescent dye /probe; histochemistry /cytochemistry; limbic system; neural conduction; neural plasticity; norepinephrine; tyrosine 3 monooxygenase

This research proposal stems from two lines of evidence: (1) chronic ethanol consumption inhibits lesion-induced axon sprouting in the adult rat and (2) maternal alcohol intake during pregnancy is detrimental to brain development and function in the offspring. Sprouting and synaptic modulation are thought to play an important role in normal CNS function therefore, the overall goal of this research is to determine the consequences of alcohol exposure in utero on neuronal plasticity. This phenomenon will be examined by studying lesion-induced sprouting in the female offspring of the alcoholic rat. The habenula will be used as a deafferentation model to study neuroplasticity, since work from this laboratory has demonstrated lesion-induced noradrenergic (NA) sprouting in this brain region. A combination of biochemical and histofluorescent techniques will be used to specifically characterize NA axon sprouting. Blood alcohol levels will be measured in a separate group of pregnants. The information derived from this work will provide important information related to the functional consequences of prenatal ethanol exposure. Furthermore, it will be of interest to both fundamental neurobiologists and clinicians.

该研究建议源于两条证据：（1）慢性 乙醇消耗抑制了成年大鼠病变引起的轴突发芽 （2）怀孕期间的孕产妇摄入对大脑有害 后代的发展和功能。 发芽和突触 人们认为调制在正常CNS功能中起重要作用 因此，这项研究的总体目标是确定 子宫内酒精暴露对神经元可塑性的后果。 这 现象将通过研究病变引起的发芽 酒精老鼠的女性后代。 Habenula将用作研究模型 神经可塑性，因为该实验室的工作已经证明 病变引起的甲肾上腺素能（Na）在该大脑区域发芽。 一个 生化和组织荧光技术的组合将用于 特别表征Na轴突发芽。 血液酒精水平将是 在单独的怀孕者中测量。 从这项工作中得出的信息将提供重要信息 与产前乙醇暴露的功能后果有关。 此外，基本神经生物学家和 临床医生。