SYMPOSIUM ON OXIDASE AND RELATED REDOX SYSTEMS

氧化酶及相关氧化还原系统研讨会

• 批准号: 3434507
• 负责人: HOWARD S. MASON
• 金额: $ 0.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434507
• 关键词: enzyme structure; oxidation reduction reaction; oxygenases; travel

We are requesting support for a 4th International Symposium on Oxidases and Related Redox Systems. Many books and symposia have recently treated restricted phases of the overall problem of structure/function in dioxygen enzymology but none has sought to define the principles which govern the functions of these proteins in general, considering all types of oxygen-active catalytic sites comparatively and at several levels of biological organization, as we now propose to do. Fifty specialized authorities will be convened to compare among these proteins: (a) the mechanisms of electron, proton, and hydride ion transfer among the proteins, substrates, cofactors, and active sites, in solution and across membranes, (b) the structural states of dioxygen in relevant aqueous and hydrophobic environments, (c) structure as a composite of results from contemporary technical probes especially X-ray crystallography, (d) mechanisms, (e) the molecular biology of oxidases, oxygenases, and oxygen-transporting proteins with respect to gene structure and sequence of the component domains, (f) mechanisms of adaptation of these proteins, and (g) their evolution in the light of various contemporary theories of evolutionary mechanisms, particularly intervention of mobile genetic elements and interspecific transfer of elements as well as more conventional processes for the generation of diversity, and (h) the mechanism and evolution of photosynthetic O2 generation. We also wish to explore certain physiological problems: the existence or not of O2 concentration gradients within cells and the nature of signals that regulate the concentration and activity of oxygen-interactive enzymes.

我们要求支持第四届国际氧化酶研讨会和 相关的氧化还原系统。 许多书籍和座谈会最近都接受过 二氧化物中结构/功能总体问题的限制阶段 酶学，但没有人试图定义管理的原则 这些蛋白质的功能一般，考虑到所有类型的 氧活性催化位点相对且在几个级别 正如我们现在建议的那样，生物组织。 将召集五十个专业当局，以比较 蛋白质：（a）电子，质子和氢化物离子转移的机制 在溶液中的蛋白质，底物，辅因子和活性位点中 （b）相关的二氧化物的结构状态（b） 水性和疏水环境，（c）结构作为复合材料 当代技术探针尤其是X射线的结果 晶体学，（d）机制，（e）氧化酶的分子生物学， 氧酶和氧转移蛋白相对于基因结构 和组件域的序列，（f）适应的机制 这些蛋白质，以及（g）根据各种 当代的进化机制理论，特别是干预 移动遗传元素和元素种间转移 作为多样性产生的更多传统过程，（h） 光合O2代的机理和演变。 我们也希望 探索某些生理问题：O2是否存在 细胞内的浓度梯度以及信号的性质 调节氧相互作用酶的浓度和活性。