TOPICS IN BIOSTATISTICS

生物统计学主题

基本信息

批准号：
3182241
负责人：
JAMES Alexander KOZIOL
金额：
$ 14.52万
依托单位：
SCRIPPS CLINIC AND RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-08-01 至 1991-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3182241
关键词：
breast neoplasms cancer information system carcinogen testing data collection methodology /evaluation dosage environment related neoplasm /cancer human mortality human therapy evaluation mathematical model statistics /biometry

项目摘要

The proposed research involves the following subject areas: survival analysis, classification and non-linear regression, the low-dose extrapolation problem, and statistical deconvolution and regularization. Among the topics planned for consideration are: an investigation of the efficiencies of goodness-of-fit procedures with censored data; a modification of the Gehan test or the Mantel-Haenszel test for the sequential analysis of randomly censored data; the development of a test for trend in survival distributions with randomly cnesored data; a theoretical investigation of questions concerning recursive partitioning schemes raised in previous research; the application of recursive partitioning schemes to the analysis of data sets collected by Dr. D. Morton of UCLA and by Dr. C. Zippin of UCSF; the development of a new technique of effecting the low-dose extrapolation procedure, the technique being related to D.R. Cox's proportional hazards models; a theoretical and empirical investigation of the effectiveness and resolvability of various methods of handling the low-dose extrapolation problem; an investigation of methods for deconvolving estimated probability density functions.

拟议的研究涉及以下主题领域：生存分析，分类和非线性回归、低剂量外推问题、以及统计反卷积和正则化。在计划的主题中考虑因素是：对拟合优度效率的调查审查数据的程序； Gehan 测试的修改或用于随机删失数据的序贯分析的 Mantel-Haenszel 检验；这随机删减生存分布趋势检验的开发数据;有关递归划分问题的理论研究先前研究中提出的方案；递归划分的应用加州大学洛杉矶分校 D. Morton 博士收集的数据集分析方案加州大学旧金山分校 (UCSF) 的 C. Zippin 博士；开发一种新技术来实现低剂量外推程序，该技术与 D.R.考克斯的比例风险模型；的理论和实证研究处理低剂量的各种方法的有效性和分辨率外推问题；去卷积估计方法的研究概率密度函数。