NON STANDARD MODELS FOR STUDY OF COGNITIVE ERPS

认知 ERPS 研究的非标准模型

• 批准号: 3411544
• 负责人: THEODORE H BULLOCK
• 金额: $ 12.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3411544
• 关键词: Aves; Cephalopoda; Chondrichthyes; Osteichthyes; Reptilia; alternatives to animals in research; behavior; biological models; brain electrical activity; brain stem; cognition; discrimination learning; electrical potential; electroencephalography; evoked potentials; histology; microelectrodes; model design /development; neural information processing; psychological reinforcement; retina; stimulus /response; stimulus generalization; systematic biology

We will continue to examine nonmammalian species for evidence of Event Related Potentials (ERPs) under the paradigms of stimulation that cause cognitive events (thoughts) and waves in humans. Selected species will be tested with many recording semimicroelectrodes chronically placed on or in the brain. Stimulus situations include (i) omitted stimuli in a monotonous series, (ii) "oddball' stimuli of low probability in such a series, including ethologically significant ones, (iii) "mismatch" stimuli, overlapping with the foregoing, (iv) reinforced paradigms used for Contingent Negative Variation (CNV) and discriminant P300-like waves, and (v) for favorable species, tailored to their ethology, incongruous termination of an expected sequence such as bird calls slightly altered from the normal. The variables to be examined, for each of the waves discovered are (a) the form, polarity and time course under various stimulus conditions, (b) alterations in dynamics with stimulus repetition and temporal pattern, (c) distribution among parts of the brain, including subcortical and brainstem levels and the retina, (d) distribution among phyla and classes of animals, including especially elasmobranchs, teleost fish and reptiles, but also cephalopods and birds, (e) behavioral and brain variables chosen to estimate the degree to which waves are sensitive to changes in state (endogenic). Finding, validating and characterizing model species among lower animals is regarded as a necessary antecedent to assessing the behavioral and cognitive significance of ERPs and to the future use of lower species for analytical physiology, anatomy and pharmacology of these waves.

我们将继续检查非哺乳动物物种，以证明 事件相关电位（ERP）在刺激范式下 引起人类的认知事件（思想）和波浪。 选定物种 将通过许多记录半electrodes进行测试 在大脑上或大脑中。 刺激情况包括（i）省略刺激 单调序列，（ii）“在这种情况下低概率的奇数刺激 系列，包括具有伦理学意义的系列，（iii） “不匹配”刺激，与前述重叠，（iv）加强 用于偶然性负变化（CNV）和判别的范例 p300的波和（v）适合其量身定制的物种 伦理学，诸如鸟类等预期序列的不协调终止 呼叫从正常情况下略有更改。 要检查的变量，因为发现的每一个波浪都是 （a）在各种刺激条件下的形式，极性和时间过程， （b）刺激重复和时间的动力学改变 模式，（c）大脑部分之间的分布，包括皮层下 和脑干水平以及视网膜，（d）门和分布 尤其包括弹性弹性，硬骨鱼和包括的动物类别 爬行动物，还有头足动物和鸟类，（e）行为和大脑 选择的变量用于估计波对波的敏感程度 状态变化（内源性）。 发现，验证和表征较低的模型物种 动物被认为是评估行为的必要前提 ERP的认知意义以及对较低物种的未来使用 对于分析生理，这些波的解剖学和药理学。