ALZHEIMER'S DISEASE AND NORMAL AGING:MR VOLUME MEASURES

阿尔茨海默病和正常衰老：MR 容量测量

• 批准号: 2267374
• 负责人: RONALD C PETERSEN
• 金额: $ 16.19万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-15 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2267374
• 关键词: Alzheimer's disease; aging; brain disorder diagnosis; centenarian human (100+); cognition disorders; dementia; diagnosis quality /standard; hippocampus; human old age (65+); human subject; human very old age (85+); longitudinal human study; magnetic resonance imaging; memory disorders; neuroanatomy; neuropsychological tests; statistics /biometry; temporal lobe /cortex

This project is designed to use a non-invasive imaging technique to improve the accuracy of the clinical diagnosis of dementia of the Alzheimer's type (DAT). While imaging techniques are currently being used to exclude other causes of dementia, this project will evaluate the role of magnetic resonance (MR)-based volume measurements of the temporal lobe in improving the clinical diagnosis. The study will draw upon two resources of the Mayo Clinic: the Mayo Clinic Alzheimer's Disease Patient Registry (ADPR) and an MR-based measurement technique developed at Mayo to measure the volumes the anterior temporal lobe (ATL), medial temporal lobe (MTL), and hippocampal formation (HF). The Mayo Clinic ADPR has been enrolling patients and control subjects for four years and consequently has a mechanism in place to evaluate and diagnose patients for the current project. The MR-volume technique has been developed and its accuracy and reproducibility validated. The present study proposes to apply this technique to 3 groups: patients with DAT, a group of mildly impaired patients, and a group of age, sex, and education matched control subjects to determine if MR can differentiate among the groups on the basis of volumetric measures of the ATL, MTL, and HF. The study will also evaluate the relationships among age, memory function, and severity of dementia (if appropriate) within the three groups. The project will extend over three years and will involve a total of 75 DAT patients, 36 mildly impaired patients, and Ill appropriately matched control subjects. We anticipate that MR measurements of the ATL, MTL, and in particular,, the HF will discriminate between patients with DAT and control subjects in a sensitive and specific fashion. In addition, we anticipate that the ATL, MTL, and in particular, the HF will decrease in volume with age but that the decline will be most pronounced for patients with DAT. Similarly, the volume of the temporal lobe structures, in particular the HF, will correlate directly with clinical indices of memory function in all three groups and in the DAT group will correlate inversely with dementia severity. In sum, we are proposing that measurement of volumetric indices of temporal lobe structures will be a sensitive and specific method of non-invasively distinguishing among patients with DAT, mild cognitive impairment, and normal elderly individuals.

该项目旨在使用非侵入性成像技术来改善 阿尔茨海默病型痴呆临床诊断的准确性 （数据）。 虽然目前正在使用成像技术来排除其他 痴呆症的原因，该项目将评估磁力的作用 基于磁共振 (MR) 的颞叶体积测量可改善 临床诊断。 该研究将利用梅奥的两项资源 诊所：梅奥诊所阿尔茨海默病患者登记处 (ADPR) 和 梅奥开发的基于 MR 的测量技术用于测量 前颞叶 (ATL)、内侧颞叶 (MTL) 和海马 形成（HF）。 梅奥诊所 ADPR 已招募患者并 控制对象四年，因此有一个机制 评估和诊断当前项目的患者。 MR 体积 技术已经开发出来，其准确性和再现性 已验证。 本研究建议将此技术应用于 3 组： 患有 DAT 的患者、一组轻度受损的患者和一组年龄， 性别和教育程度与对照受试者相匹配，以确定 MR 是否可以 根据体积测量来区分各组 ATL、MTL 和 HF。 该研究还将评估之间的关系 年龄、记忆功能和痴呆的严重程度（如果适用） 三组。 该项目将持续三年多，并涉及 总共 75 名 DAT 患者、36 名轻度受损患者和 1 名重病患者 适当匹配的对照对象。 我们预计 ATL、MTL 的 MR 测量，特别是 HF 将区分 DAT 患者和对照受试者 敏感而具体的时尚。 此外，我们预计 ATL、 MTL，特别是 HF 的音量会随着年龄的增长而减小，但 DAT 患者的下降最为明显。 同样， 颞叶结构的体积，特别是高频，将 与所有三个方面的记忆功能临床指标直接相关 组和 DAT 组与痴呆症呈负相关 严重程度。 总之，我们建议测量体积指数 颞叶结构的研究将是一种敏感而具体的方法 无创区分 DAT 患者、轻度认知障碍患者 损伤和正常老年人。