EVOKED POTENTIALS IN CONGENITAL HIV INFECTION

先天性 HIV 感染的诱发潜力

• 批准号: 3412545
• 负责人: RON G. EMERSON
• 金额: $ 18.01万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3412545
• 关键词: AIDS; HIV infections; cognition disorders; congenital infection; evoked potentials; human immunodeficiency virus; human subject; infant human (0-1 year); nervous system disorder diagnosis; nervous system infection; preschool child (1-5); sensorimotor system

The overall goal if this study is to evaluate median nerve somatosensory evoked potentials as an objective measure of HIV encephalopathy in children. We will examine whether, as our preliminary data strongly suggest, HIV infection in children is associated with characteristic alterations in median nerve SEPs. We will described the evolution of these alterations over time. We will determine whether median nerve SEP abnormalities are correlated with neurologic or cognitive deficits, and whether these abnormalities are detectable prior to the onset of clinically evident disease. We also will examine the relationship between development of SEP abnormalities and virologic measures of HIV infection and immune status. The study will draw on approximately 80 children born to mothers at increased risk of HIV infection and for whom detailed clinical and psychometric data will be available. An estimated 25 to 30 children infected with HIV prenatally or in the perinatal period will be compared to 50 uninfected children. The sample will be followed repeatedly up to three years of age with serial median nerve SEP studies.

如果这项研究是评估中位神经的总体目标 体感诱发潜力作为艾滋病毒的客观度量 儿童的脑病。 我们将研究是否作为我们的 初步数据强烈表明，儿童的艾滋病毒感染是 与中位神经SEP的特征变化有关。 我们将随着时间的流逝描述这些改变的演变。 我们将确定中位神经SEP异常是否为 与神经系统或认知缺陷相关，以及这些是否存在 在临床上发作之前，可以检测到异常 明显的疾病。 我们还将检查 艾滋病毒的SEP异常和病毒学测量的发展 感染和免疫状态。 这项研究将借鉴母亲出生的大约80个孩子 艾滋病毒感染的风险增加，并为其详细的临床 和心理测量数据将可用。 估计25至30 在产前或围产期感染HIV的儿童 将与50名未感染的儿童进行比较。 样本将是 紧随其后的是三岁以后的连续中位数 神经sep研究。