STRUCTURAL CORRELATES OF CORTICAL INFORMATION PROCESSING

皮质信息处理的结构相关性

• 批准号: 3408248
• 负责人: SHARON L JULIANO
• 金额: $ 5.52万
• 依托单位: HENRY M. JACKSON FDN FOR THE ADV MIL/MED
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3408248
• 关键词: Macaca; Saimiri; adrenergic receptor; cats; evoked potentials; gamma aminobutyrate; neuroanatomy; neurotransmitter metabolism; neurotransmitter receptor; neurotransmitters; nicotinic receptors; sensory cortex

The proposed studies will investigate the cortico-cortical structure in the primary somatosensory cortex (SI) of normal animals (cats and primates) and enable a direct comparison in the same brain of cortical connectivity patterns with evoked functional activity. The relationships between structure and function will also be evaluated in states which disrupt neurotransmitter input to the cortex and are known to mimic human diseases which effect cognitive function. The neurotransmitter system chosen for study are implicated in playing a role in sensory cortical processing and include: the adrenergic, the cholinergic and the GABAergic. The first phase of experimentation will establish patterns of cortico-cortical connectivity in SI (comprised of cytoarchitectonic areas 3a, 3b, 1 and 2) through the use of anterograde and retrograde tracers. The labeling patterns will be produced by small injections of tracers into physiologially identified regions of somatosensory cortex. After the anatomical patterns are established, the second phase of study will investigate the relationship between the cortico-cortical connections and functional activity (as determined by 2-deoxyglucose labeling). It is expected that both within and between cytoarchitectonic fields, the locations of the cortico-cortical connections and the evoked metabolic activity produced by appropriate stimuli will be highly correlated. The third phase of study will evaluate the stimulus-evoked metabolic activity produced following manipulations which are known to disrupt the cortical supply of specific neurotransmitters. The manipulations will take the form of either surgical/chemical lesions or pharmacologic treatment with agonists or antagonists of the neurotransmitters. Finally, the cortico-cortical structural relationships and the stimulus-evoked 2-deoxyglucose labeling will be ascertained under the manipulated conditions. It is anticipated that in the altered conditions, the correspondence between cortico-cortical structure and functional activity revealed with 2-deoxyglucose will be less rigid than in the normal animals. Instead the effect changing the cortical modulatory influence of specific neurotransmitters should be strongly reflected in alterations in the metabolic pattern and weakly reflected, if at all, in the intrinsic cortico-cortical connections.

拟议的研究将研究在 普通动物（猫和灵长类动物）的原发性体感皮质（SI）和 在皮质连通性的相同大脑中进行直接比较 具有诱发功能活动的模式。 之间的关系 结构和功能也将在破坏的状态中进行评估 神经递质输入皮质，并知道模仿人类疾病 哪个影响认知功能。 选择的神经递质系统 研究与在感觉皮质处理中发挥作用，并 包括：肾上腺素能，胆碱能和GABA能。 第一个 实验阶段将建立皮质皮质的模式 SI的连通性（由细胞结构区域3a，3b，1和2组成） 通过使用顺行和逆行示踪剂。 标签 图案将通过少量的示踪剂注射到 体感皮质的生理鉴定区域。 之后 建立了解剖模式，第二阶段的研究将 研究皮质皮质连接与 功能活性（如2-脱氧葡萄糖标记确定）。 这是 期望在细胞结构域内和之间 皮质皮质连接的位置和唤起的代谢 适当刺激产生的活动将高度相关。 这 研究的第三阶段将评估刺激诱发的代谢活性 生成以下操纵，已知会破坏皮质 特定神经递质的供应。 操纵将采用表格 手术/化学病变或药理治疗 神经递质的激动剂或拮抗剂。 最后， 皮质皮质结构关系和刺激诱发的 在操纵下将确定2-脱氧葡萄糖标记 状况。 预计在改变的情况下 皮质皮质结构与功能活性之间的对应关系 用2-脱氧葡萄糖揭示的要比正常 动物。 相反，效果改变了皮质调节的影响 特定的神经递质应强烈反映在改变 代谢模式，在固有的 皮质皮质连接。