EPIDEMIOLOGIC STUDY OF STROKE OUTCOME IN 3 ETHNIC GROUPS

3个民族脑卒中结果的流行病学研究

• 批准号: 3413814
• 负责人: Ralph L. Sacco
• 金额: $ 11.57万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3413814
• 关键词: African American; Hispanic Americans; Native Americans; alcoholic beverage consumption; atherosclerosis; cardiovascular disorder epidemiology; case history; cerebrovascular occlusions; diabetic angiopathy; diabetic neuropathy; disease /disorder proneness /risk; embolism; heart disorder; human age group; human mortality; hypercholesterolemia; infarct; interview; lifestyle; myocardial infarction; questionnaires; racial /ethnic difference; relapse /recurrence; sign /symptom; stroke; tobacco abuse; African American; Hispanic Americans; Native Americans; alcoholic beverage consumption; atherosclerosis; cardiovascular disorder epidemiology; case history; cerebrovascular occlusions; diabetic angiopathy; diabetic neuropathy; disease /disorder proneness /risk; embolism; heart disorder; human age group; human mortality; hypercholesterolemia; infarct; interview; lifestyle; myocardial infarction; questionnaires; racial /ethnic difference; relapse /recurrence; sign /symptom; stroke; tobacco abuse

Despite the reported decline in the incidence of stoke, there has not been a decline in stroke recurrence. Relatively little is known about whether ethnicity, independently or in conjunction with stroke risk factors, determines outcome after cerebral infarction. Most epidemiologic studies have been conducted predominately white populations. Less is known about black survivors of cerebral infarction, and few studies have been done in the growing Hispanic population. The study is designed to determine in whites, blacks and Hispanics the risk of stroke recurrence, myocardial infarction and death in 30 day survivors of cerebral infarction up to 10 years after an index event. Members of the cohort were admitted to the Neurological Institute of New York from 1983 to 1988. The majority are from Northern Manhattan, a community with many black and Hispanic residents. Columbia-Presbyterian Medical Center is the main provider of ambulatory and hospital care for this community. Risk factors for stroke, infarct subtype, adn findings on neurological examination and diagnostic studies, identified at the time of the initial cerebral infarction, have already been collected on the systematically evaluated cohort. Annual telephone follow-up of the patient or next of kin will be used to measure changes in risk factors and to identify those with stroke recurrence, symptomatic myocardial infarction or death. In-person follow-up interview and examination will be done on patients suspected of a subsequent event. Outcome after cerebral infarction will be analyzed by life table methods and Cox proportional hazards modelling. Stratification r the addition of other collected variables to the models are expected to show that the effect of ethnicity is not independent of other risk factors. Besides gaining new epidemiologic information on the risk and determinants of stoke recurrence, myocardial infarction and death after cerebral infarction in three ethnic groups, understanding the role of individual risk factors and their interactions with ethnicity will encourage more selective secondary prevention strategies.

尽管据报道斯托克发病率下降，但没有 中风复发的下降。相对鲜为人知 无论种族，独立还是与中风风险结合 因素，决定脑梗塞后的结果。 最多 流行病学研究主要是白人 人群。 关于大脑的黑人幸存者知之甚少 梗塞，很少有研究对发展的西班牙裔研究 人口。 该研究旨在确定白人，黑人和西班牙裔 30天内的中风复发，心肌梗塞和死亡的风险 指数事件发生后长达10年，脑梗塞的幸存者。 该队列的成员被接纳为新的神经学研究所 约克（York）从1983年到1988年。大多数来自曼哈顿北部 有许多黑人和西班牙裔居民的社区。哥伦比亚长老会 医疗中心是门诊和医院护理的主要提供商 这个社区。 中风的危险因素，梗塞亚型，ADN发现 关于神经系统检查和诊断研究，在 最初的大脑梗塞的时间已经收集在 系统评估的队列。 年度电话随访 患者或亲属的近亲将用于衡量风险因素的变化 并识别患有症状心肌的中风复发的人 梗塞或死亡。 面对面的后续采访和考试将 可以对怀疑随后事件的患者进行。 生命表方法将分析脑梗塞后的结果 和Cox比例危害建模。 分层r添加 在模型的其他收集变量中，预计将表明 种族的影响并非独立于其他风险因素。除了 获得有关风险和决定因素的新的流行病学信息 斯托克复发，心肌梗塞和脑死亡 在三个族裔中的梗塞，了解个人的作用 风险因素及其与种族的互动将鼓励更多 选择性二级预防策略。