WHAT DISTINGUISHES WATER IN CANCER AND IN NORMAL TISSUES

癌症和正常组织中的水有什么区别

• 批准号: 3164362
• 负责人: GILBERT N LING
• 金额: $ 15.59万
• 依托单位: PENNSYLVANIA HOSPITAL (PHILADELPHIA)
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-06-01 至 1988-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3164362
• 关键词: adenosine triphosphate; adsorption; biophysics; calorimetry; cell osmotic pressure; cell water; cellular oncology; chemical hydration; electron microscopy; fluidity; ion transport; malignant ascites; membrane model; membrane permeability; molecular polarity; neoplastic cell; nonelectrolyte transport; nuclear magnetic resonance spectroscopy; pentoses; physical property; polymerization; polymers; potassium; relaxation spectrometry; sodium; solute; water solubility

Water makes up from 75 to 85% of all living matter. Thus water is not only the medium in which all biomedical reactions take place, it is also by far the major substance of living matter. For these fundamental reasons, the discovery that water in cancer cells has longer NMR relaxation time (T1 and T2) is of great potential importance. Having established that these longer T1 and T2 are not due to the larger water contents but are distinctly different from all normal host animal tissues but are very similar among all variety of cancer cells of diverse origin, our immediate plan for the next year would encompass both fundamental inquiries of the physico-chemical basis for differences in T1 and T2 of model systems as well as living cells. We will also continue our investigation of the different T1 and T2 of host tissues from cancer-bearing animals particularly in relation to animals bearing "red ascites" and bearing "yellow ascites" with the hope of understanding more about the process of cancer cell dissemination.

水占所有生命物质的 75% 至 85%。 因此水不仅是 所有生物医学反应发生的介质，它也是迄今为止主要的介质 生命物质的实质。 由于这些根本原因，发现 癌细胞中的水具有较长的NMR弛豫时间（T1和T2）非常重要 潜在的重要性。 确定这些较长的 T1 和 T2 不是 由于含水量较大，但与所有正常情况明显不同 宿主动物组织，但各种癌细胞之间非常相似 不同的起源，我们明年的近期计划将包括 T1 和 T2 差异的物理化学基础的基本调查 模型系统以及活细胞。 我们也将继续我们的 宿主组织与癌症荷瘤组织不同 T1 和 T2 的研究 动物，特别是与带有“红色腹水”和带有“红色腹水”的动物有关 “黄色腹水”希望更多地了解癌症的进程 细胞传播。