EPIDEMIOLOGY OF MIGRAINE HEADACHE

偏头痛的流行病学

• 批准号: 3399429
• 负责人: MOYSES A SZKLO
• 金额: $ 39.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-09 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3399429
• 关键词: adolescence (12-20); disease /disorder classification; disease /disorder proneness /risk; environmental stressor; gender difference; interview; migraine; nervous system disorder epidemiology; neuroendocrine system; personality; psychological stressor; psychosomatic disorders; questionnaires; stress; young adult human (21-34)

Migraine headache is a common, recurrent, severe and often incapacitating condition estimated to affect 4-19% of adult men and 8-29% of adult women. One survey showed that severe headache is responsible for almost 10 million outpatient visits to physicians per year. The primary objectives of the proposed two-phase study are 1) to determine the prevalence of migraine, 2) to further refine the definition of a case of migraine and to characterize migraine subtypes 3) to identify important risk factors associated with the development and onset of migraine headaches in recent-onset cases in a community population and 4) to identify events which precipitate specific episodes of migraine headache among cases. These objectives will be accomplished by a study consisting of two phases. First, we will conduct a population-based prevalence survey in a well-characterized American community. Second, we will perform a case-control study using 220 recent-onset (incident) migraine cases identified in the prevalence survey. The proposed population-based prevalence study would be one of the first to be carried out in an American community; results could be compared to those from other population-based epidemiologic studies carried out in Great-Britain, Israel and Denmark. The methods used in the prevalence survey will provide a means to estimate the incidence of migraine. This would be unique in that we have been unable to find reports of any other incidence study. In the prevalence survey subjects who have had a recent attack of migraine will be asked about factors which may have precipitated the attack. In contrast to a number of past studies, this study will provide more reliable data on possible precipitants. Finally, a case-control study using recent-onset cases should allow us to focus on more specific hypotheses regarding risk factors suggested by previous work, including stress, psychosocial and personality factors; hormonal factors in women; and familial factors.

偏头痛是一种常见、反复发作、严重且常常导致丧失能力的头痛 据估计，该病症影响 4-19% 的成年男性和 8-29% 的成年女性。 一项调查显示，严重头痛导致近 1000 万人 每年看医生的门诊次数。 拟议的两阶段研究的主要目标是 1) 确定 偏头痛的患病率，2）进一步细化病例的定义 偏头痛并描述偏头痛亚型的特征 3) 识别重要的 与偏头痛发生和发作相关的危险因素 社区人群中新发病例的头痛和 4) 识别导致偏头痛特定发作的事件 案件之间。 这些目标将通过一项研究来实现，该研究包括 两个阶段。 首先，我们将进行基于人群的患病率调查 在一个特色鲜明的美国社区中。 其次，我们将执行一个 使用 220 例新发（事件）偏头痛病例的病例对照研究 在患病率调查中发现。 拟议的基于人群的患病率研究将是第一个 在美国社区进行；结果可以与那些进行比较 来自其他以人群为基础的流行病学研究 英国、以色列和丹麦。 流行中使用的方法 调查将提供一种估计偏头痛发病率的方法。 这 其独特之处在于我们无法找到任何其他的报告 发生率研究。 在患病率调查中，近期有过 将询问可能引发偏头痛的因素 攻击。 与过去的一些研究相比，本研究将 提供有关可能的沉淀物的更可靠的数据。 最后，一个 使用近期发病病例的病例对照研究应该使我们能够关注 关于先前工作提出的风险因素的更具体的假设， 包括压力、心理社会和个性因素；荷尔蒙因素 女性;以及家庭因素。