MUSCLE RECEPTORS

肌肉受体

• 批准号: 3393686
• 负责人: CARLTON C HUNT
• 金额: $ 10.56万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1988-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393686
• 关键词: afferent nerve; axon; electron microscopy; evoked potentials; innervation; mechanoreceptors; membrane permeability; membrane potentials; microscopy; muscle contraction; muscle tension; myofibrils; neural information processing; neural initiation; neuromuscular junction; neuromuscular transmission; sarcomeres; stretch receptors

Mechanisms of sensory transduction and its modification by motor control will be studied in mammalian muscle spindles, both in situ and in isolated preparations. The membrane properties and contractile activation of intrafusal muscle fibers as well as their passive mechanical properties will be investigated using intracellular recording and stimulation and microscopic measurement of sarcomere length changes. The roles of the 2 types of nuclear bag fiber will be tested by activation of these fibers individually while observing the effect on the primary ending response to stretch. Possible stretch excitation in bag fibers will be studied. The conductance change in the sensory terminals in response to stretch will also be investigated as will the characteristics of impulse initiation in the primary ending.

感觉传导机制及其通过运动控制的修改 将在哺乳动物肌梭中进行原位和分离研究 准备工作。 膜特性和收缩激活 梭内肌纤维及其被动机械性能 将使用细胞内记录和刺激进行研究 显微镜测量肌节长度变化。 2 的角色 核袋纤维的类型将通过激活这些纤维来测试 单独观察对主要结束反应的影响 拉紧。 将研究袋纤维中可能的拉伸激发。 这 感觉末梢响应拉伸的电导变化 也将研究脉冲启动的特征 主要结局。