Novel drug sensor platform - bringing new technology closer to market

新型药物传感器平台——让新技术更接近市场

• 批准号: EP/J013552/1
• 负责人: Tong Sun
• 金额: $ 17.88万
• 依托单位: City, University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ013552%2F1
• 关键词: Novel; drug; sensor; platform; bringing

In the year 2010 - 2011 the UK Border Agency (UKBA) made over 1,200 individual seizures of Class-A drugs totalling 3,000kg. In August of this year alone a record-setting 1.2 tons of cocaine was seized in one drug bust aboard a pleasure boat - an unusually high amount for one bust but a level of success the UKBA wants to maintain.There is a range of drug detection equipment on the market today, but each has its strengths and limitations, including sniffer dogs, which are often considered one of the most efficient and highly sensitive means for drug detection. The limitations of existing technologies include high levels of false alarms, low levels of sensitivity compared to sniffer dogs and high cost using disposable consumables. Specifically with regards to dogs, high upkeep cost and a dog's nature of getting tired or confused, and inability to act as evidence in a court of law, are all big issues. The team at City is proposing to develop a prototype real-time multi-drug sensing detection system to address the above challenge and this builds upon the success of the initial EPSRC project, where a novel, highly sensitive and selective optical fibre-based portable cocaine sensor, using the molecularly imprinting polymer (MIP) technique coupled with fluorescence signalling, has been successfully developed and evaluated. The Home Office CAST members were instrumental in identifying the need as an end-user for this new sensor technology exploitation and its associated new drug sensor development. They, together with advisors from Smiths Detection, are shaping the main deliverables of this proposal to ensure that it results in a commercially robust product. Initially the device will be developed to detect drugs concealed in hard-to-reach areas in vehicles or containers crossing borders, where currently sniffer dogs are frequently used to locate the illegal substance. However, the underlying technology is capable of meeting a much wider range of applications. This follow-on funding is vital for the team to develop the technology to a stage that it can be licensed to an existing manufacturer, currently supplying drug detection devices to the Border Security Agencies around the world. City's technology transfer team will be an integral part of this project, carrying out simultaneous market validation exercises and feeding back to the academic team on a continual basis. This intelligence will advise the product development process. The team will also work with the in-house Incubator to establish whether an additional or alternative route to market could involve creating a spin-out company capable of attracting seed investment.

在2010年至2011年，英国边境机构（UKBA）对总计3,000公斤的A级药物进行了1,200多次癫痫发作。仅在今年的8月，仅在一艘娱乐船上占有一台药物爆发中的创纪录的1.2吨可卡因 - 一个非常高的损失数量，但英国巴布想要维持的成功水平。当今市场上有一系列药物检测设备，但每种药物都具有其优势和极限，包括其优势和限制，包括最有效的niffer狗，被认为是高度效率的药物，并且对药物有效，并且对药物的意义高度敏感，并且具有敏感的药物，并且是一种敏感的药物。现有技术的局限性包括高水平的错误警报，与嗅探犬相比的敏感性低以及使用一次性消耗品的高成本。特别是关于狗，高昂的保养成本以及狗的疲倦或困惑的本质，以及无法在法庭上充当证据的性质，都是大问题。城市的团队正在建议开发一个原型实时多毒传感检测系统，以应对上述挑战，这是基于最初的EPSRC项目的成功，在该项目的成功基础上，该项目是一种新颖的，高度敏感的和选择性的基于光纤的可卡因传感器，使用分子上压印聚合物（MIP）技术，已成功地进行了fluoresence and Insperction coupling and Insperiment and Inspection。内政部的演员在确定这一新传感器技术开发及其相关的新药传感器开发的最终用户方面发挥了作用。他们与史密斯检测的顾问一起塑造了该提案的主要可交付成果，以确保其产生商业上强大的产品。最初，该设备将被开发出来，以检测横穿边界的车辆或容器的难以到达区域中的药物，目前经常使用Sniffer Dogs来定位非法物质。但是，基础技术能够满足更广泛的应用程序。这项后续资金对于团队将技术开发到可以将其许可的阶段开发给现有制造商的阶段至关重要，目前为世界各地的边境安全机构提供药物检测设备。曼城的技术转移团队将是该项目不可或缺的一部分，同时进行市场验证练习，并不断地向学术团队馈回学术团队。这种情报将为产品开发过程提供建议。该团队还将与内部孵化器合作，以确定一条额外的或替代市场的途径是否涉及创建能够吸引种子投资的纺纱公司。

项目成果

Preparation of novel optical fibre-based Cocaine sensors using a molecular imprinted polymer approach

• DOI: 10.1016/j.snb.2013.11.071
• 发表时间: 2014-03
• 期刊: Sensors and Actuators B-chemical
• 影响因子: 8.4
• 作者: S. Wren;T. H. Nguyen;P. Gascoine;R. Lacey;T. Sun;K. Grattan

Computational Design and Fabrication of Optical Fibre Fluorescent Chemical Probes for the Detection of Cocaine

用于检测可卡因的光纤荧光化学探针的计算设计和制造

• DOI: 10.1109/jlt.2015.2389036
• 发表时间: 2015
• 期刊: Journal of Lightwave Technology
• 影响因子: 4.7
• 作者: Wren S

Novel coumarin-based pH sensitive fluorescent probes for the highly alkaline pH region

• DOI: 10.1016/j.dyepig.2020.108312
• 发表时间: 2020-06-01
• 期刊: DYES AND PIGMENTS
• 影响因子: 4.5
• 作者: Nguyen, T. Hien;Sun, Tong;Grattan, Kenneth T., V
• 通讯作者: Grattan, Kenneth T., V

Wavelength-based localized surface plasmon resonance optical fiber biosensor

• DOI: 10.1016/j.snb.2013.02.052
• 发表时间: 2013-05-01
• 期刊: SENSORS AND ACTUATORS B-CHEMICAL
• 影响因子: 8.4
• 作者: Cao, Jie;Tu, Minh Hiue;Grattan, Kenneth T. V.
• 通讯作者: Grattan, Kenneth T. V.

Intrinsic Fluorescence-Based Optical Fiber Sensor for Cocaine Using a Molecularly Imprinted Polymer as the Recognition Element

• DOI: 10.1109/jsen.2011.2158537
• 发表时间: 2012-01-01
• 期刊: IEEE SENSORS JOURNAL
• 影响因子: 4.3
• 作者: Nguyen, T. Hien;Hardwick, Sheila A.;Grattan, Kenneth T. V.
• 通讯作者: Grattan, Kenneth T. V.