OUTCOME OF PRIMARY CARE DEPRESSIVE DISORDER SUBTYPES

初级保健抑郁症亚型的结果

• 批准号: 3385564
• 负责人: JAMES E. BARRETT
• 金额: $ 10.83万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3385564
• 关键词: antidepressants; clinical depression; disease /disorder classification; human subject; imipramine; longitudinal human study; mental disorder chemotherapy; mental disorder diagnosis; patient care management

Services research has shown that depressive disorders are common, with a prevalence of 15-20%, in primary care. The diagnostic categories currently in use to classify these patients, and ultimately to guide their treatment, have come from the speciality sector of psychiatry. Recent epidemiologic research has shown that these speciality derived categories have limited applicability in primary care, and that there are other depressive disorder presentations in primary care which do not easily fit into the available categories of the official psychiatry nosology. The specific aim of this proposal is to obtain longitudinal outcome data on four depressive disorder presentations established as common in primary care. The four disorders include two which have been previously defined (RDC episodic minor depressive disorder; RDC chronic intermittent depressive disorder) and two which are suggested by DSM-II categories but which are not well defined under that system (mixed anxiety depression and suspected/masked depression). Explicit criteria for the latter two categories will be developed and tested for reliability and comprehensibility to primary care providers. The study then follows a longitudinal design, obtaining clinical outcome data by psychiatric interview one year after each targeted depressive disorder has been identified by the primary care provider. The outcome data will include treatment response to a commonly recommended anti-depressant, imipramine, as well as course and functional status over the one year follow-up interval. The focus of this research is on depressive presentation as they occur in the routine day-to-day practice of primary care providers. It seeks to establish valid categories for those presentations which will be accepted by primary care providers and which will relate directly to management and treatment.

服务研究表明抑郁症很常见，其中 在初级保健中，患病率为 15-20%。 目前的诊断类别 用于对这些患者进行分类，并最终指导他们的治疗， 来自精神病学专业领域。 近期流行病学 研究表明，这些专业派生类别有限 在初级保健中的适用性，以及还有其他抑郁症 初级保健中的介绍不容易适应现有的情况 官方精神病学分类学的类别。 该提案的具体目标是获得以下方面的纵向结果数据： 四种抑郁症表现在原发性抑郁症中很常见 关心。 这四种疾病包括先前定义的两种 （RDC 阵发性轻度抑郁症；RDC 慢性间歇性 抑郁症）和 DSM-II 类别建议的两个，但 在该系统下没有明确定义（混合焦虑抑郁和 疑似/隐匿性抑郁症）。 后两者的明确标准 将开发和测试类别的可靠性和 初级保健提供者的理解性。 然后该研究遵循 纵向设计，通过精神病学获得临床结果数据 每次有针对性的抑郁症治疗一年后进行访谈 由初级保健提供者确定。 结果数据将包括 对常用抗抑郁药丙咪嗪的治疗反应 以及一年随访期间的病程和功能状态 间隔。 这项研究的重点是抑郁症的表现，因为它们发生在 初级保健提供者的日常实践。 它力求 为将被接受的演示文稿建立有效类别 由初级保健提供者提供，这将直接关系到管理和 治疗。