BEHAVIORAL ANALYSIS OF SENSORY NEOCORTEX

感觉新皮质的行为分析

• 批准号: 3374556
• 负责人: IRVING T DIAMOND
• 金额: $ 28.47万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3374556
• 关键词: Prosimii; agglutinins; association cortex; auditory pathways; brain mapping; brain stem; cholinergic receptors; corpus striatum; electron microscopy; evoked potentials; experimental brain lesion; fluorescence microscopy; fluorescent dye /probe; immunocytochemistry; mesencephalon; microinjections; neocortex; neuropsychology; ophthalmoscopy; psychobiology; radiotracer; reticular formation; sensory cortex; somatostatin; stimulus /response; superior colliculus; synapses; thalamic nuclei; visual pathways; visual stimulus

The long term objective is to achieve a better understanding of the association cortex and its relation to the primary sensory cortex. The neocortex is the highest level of the brain and the study therefore has implication for mental health. The starting point for the proposed research is the discovery that association cortex as well as the sensory cortex is the target of sensory pathways that are relayed by the dorsal thalamus. The questions raised in the specific aims concern differences in the primary and secondary pathways. Each pathway is influenced, but not in the same way by centers in the brain stem that are not modality-specific -- the reticular formation and the reticular nucleus. The aim is to identify the functional significance of the modulating influences and their differences. The targets of the secondary pathways in the cortex and the cortical layers of terminations must be identified to understand the relation between sensory and association cortex inasmuch as the areas called "association cortex" receive thalamic projections from the secondary pathways. Cortico-cortical connections and descending projections from cortex can be viewed as the basis for integration between primary and secondary pathways.

长期目标是更好地理解 关联皮层及其与主要感觉皮层的关系。 这 新皮层是大脑的最高水平，因此研究具有 对心理健康的影响。 提议的起点 研究是结合皮层和感觉的发现 皮层是背面传递的感觉途径的目标 丘脑。 特定目的提出的问题涉及 主要和次要途径。 每条途径都受到影响，但没有 大脑茎中的中心相同的方式不是特定于模态的 - 网状形成和网状核。 目的是确定 调节影响及其功能意义 差异。 皮质和次级途径的目标和 必须确定终止的皮层层以了解 感觉和关联皮层之间的关系是区域 称为“协会皮质” 途径。 皮质皮层连接和下降预测 皮质可以看作是主要和之间集成的基础 次要途径。