BEHAVORIAL ANALYSIS OF SENSORY NEOCORTEX

感觉新皮质的行为分析

• 批准号: 3374552
• 负责人: IRVING T DIAMOND
• 金额: $ 22.9万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3374552
• 关键词: association cortex; auditory cortex; auditory nuclei; auditory pathways; brain mapping; brain stem; cognition; corpus striatum; electrophysiology; experimental brain lesion; fluorescent dye /probe; lateral geniculate body; learning; neurons; neurophysiology; neuropsychology; newborn animals; occipital lobe /cortex; psychobiology; pulvinar thalami; radionuclide double label; retina; sensory cortex; stereoradiography; superior colliculus; thalamus; visual cortex; visual pathways; visual perception

The objective is to understand the relation between the sensory and association areas of the neocortex. Since the neocortex is the hallmark of man, the research proposed promises to reveal the neural basis for perception, learning and cognition. The proposal is to continue using the three shrew (Tupaia glis) as a model for higher primates. Earlier studies in this laboratory showed that the association visual cortex in Tupaia is the target of a sensory pathway originating in the tectum and relaying in the pulvinar nucleus. Tupaia provides a unique opportunity to learn more about the functional relation between th tecto-pulvinar and the geniculo-striate pathways because the behavioral deficits after ablation of either pathway alone is not incapacitating. Behavioral experiments are proposed to test acuity, pattern vision, and visual learning after ablation of the pulvinar nucleus or the striate cortex. Anatomical experiments are proposed to identify subdivisions of the pulvinar nucleus in Tupaia and their connections to cortex. Immunocytochemical and HRP transport studies are proposed to learn more about the projections of the reticular formation to the dorsal thalamus (and to the lateral geniculate and pulvinar nuclei, in particular). The use of antisera will identify terminals according to their neurotransmitter; serotonin, acetylcholine, and noradrenalin. Galago and Saimiri will be used in addition to Tupaia. Finally, it is proposed that the study of the laminar organization in striate cortex of lateral geniculate terminals be continued using the methods of intracellular injection and electron microscopy.

目的是了解感官与 新皮层的关联区。 由于新皮层是 拟议的研究有望揭示神经基础的研究 感知，学习和认知。 该提议是继续使用 三尖（Tupaia Glis）作为高级灵长类动物的模型。 较早的研究 在这个实验室中表明，图帕中的视觉皮层是 感官途径的目标，该途径起源于底座和中继 pulvinar核。 Tupaia提供了一个独特的机会来了解更多 关于Tecto-Pulvinar和The的功能关系 Geniculo-STRIATE途径，因为消融后的行为缺陷 仅两个途径都不是无行为能力。 行为实验是 提议在消融后测试敏锐度，模式视觉和视觉学习 pulvinar核或侧层皮质的含量。 解剖实验是 提议确定图帕和 它们与皮质的连接。 免疫细胞化学和HRP转运研究 建议更多地了解网状形成的预测 到背丘脑（以及侧向二核和pulvinar核， 尤其）。 使用反塞将根据 他们的神经递质； 5-羟色胺，乙酰胆碱和去甲肾上腺素。 加拉戈 Saimiri还将用于Tupaia。 最后，提议 对横向皮层的层层组织的研究 使用细胞内的方法继续进行基因末端 注射和电子显微镜。