RESPIRATORY SENSATION IN NORMAL AND ASTHMATIC CHILDREN

正常儿童和哮喘儿童的呼吸感觉

• 批准号: 3367947
• 负责人: PAUL W DAVENPORT
• 金额: $ 15.42万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3367947
• 关键词: adolescence (12-20); afferent nerve; asthma; brain electrical activity; brain mapping; cerebral cortex; child (0-11); evoked potentials; human subject; neural information processing; perceptual distortions; pulmonary respiration; respiratory airflow measurement

Asthma is the most common cause of respiratory disability in children. Asthma deaths have increased worldwide. one of the common factors associated with asthma fatality is failure to recognize the severity of the asthma attack. It can result in an inappropriate, even fatal, delay in receiving treatment. The primary goal of this project is to investigate the neural and behavioral mechanisms which contribute to this failure to recognize the severity of their asthma. specifically, the physiological processes mediating respiratory sensation and subsequent behavioral responses will be studied in asthmatic children. These studies will test the hypothesis that the perception of mechanical loads is related to respiratory related evoked potentials (RREP). The significance of the work lies in the fact that impaired perception of loaded breathing may put some asthmatic patients at risk by causing underestimation of the severity of an attack with consequent inadequate self-medication and delay in seeking medical attention. In addition, the RREP may serve as a neurological means of identifying patients with respiratory load sensory deficits. The RREP is a unique measure of cerebral cortical neural activity elicited by breathing against a mechanical load. This technique will be used, in combination with established psychophysical measures, to test for differences in the neural processing of respiratory load information between asthmatic and non-asthmatic children. The cortical distribution of the RREP and resistive load threshold for eliciting the RREP during inspiration and expiration will be determined. This will be followed by correlation of the neural measure of mechanical load afferent activation (RREP amplitude) with subjective measures of load perception. Elevated background resistance, such as occurs in chronic asthma, will be used to test for the change in perceptual sensitivity. The ventilatory response to mechanical loads will also be correlated with the RREP and detection of the load. The results of this project will provide new information on the sensory mechanisms mediating respiratory sensation in asthmatic and non-asthmatic children. In addition, a subgroup of severe asthmatics will be identified that have a reduced perceptual acuity for mechanical loads. These results will be used to develop a better physiological understanding of self-assessment sensitivity in these children and used to provide enhanced treatment strategies.

哮喘是儿童呼吸系统疾病的最常见原因。 全球哮喘死亡人数有所增加。共同因素之一 与哮喘死亡相关的是未能认识到哮喘的严重性 哮喘发作。 它可能会导致不适当的、甚至致命的延误 在接受治疗时。 该项目的主要目标是 研究促成这一现象的神经和行为机制 未能认识到哮喘的严重程度。具体来说， 介导呼吸感觉和随后的生理过程 将研究哮喘儿童的行为反应。 这些 研究将检验机械负载感知的假设 与呼吸相关诱发电位（RREP）有关。 这 这项工作的意义在于，感知受损 负荷呼吸可能会使一些哮喘患者面临危险，因为 低估攻击的严重性而导致的不足 自我药疗和延迟就医。 此外， RREP 可作为识别患有以下疾病的患者的神经学手段 呼吸负荷感觉缺陷。 RREP 是大脑皮层神经活动的独特测量方法 通过对抗机械负荷呼吸引起。 这项技术将 与既定的心理物理措施相结合，用于测试 呼吸负荷信息的神经处理差异 哮喘儿童和非哮喘儿童之间的差异。 皮质分布 RREP 和电阻负载阈值，用于在期间引出 RREP 吸气和呼气将被确定。 接下来将是 机械负荷传入激活神经测量的相关性 （RREP 幅度）与负载感知的主观测量。 高架 背景阻力，例如慢性哮喘中发生的阻力，将用于 测试感知灵敏度的变化。 通气反应 机械负载也将与 RREP 和检测相关 负载的。 该项目的结果将提供新的信息 介导哮喘患者呼吸感觉的感觉机制 和非哮喘儿童。 此外，还有一个严重哮喘患者亚组 将被识别出对机械的感知敏锐度降低 负载。 这些结果将用于开发更好的生理学 了解这些儿童的自我评估敏感性并使用 提供增强的治疗策略。