RESPIRATORY SENSATION IN NORMAL AND ASTHMATIC CHILDREN

正常儿童和哮喘儿童的呼吸感觉

• 批准号: 3367947
• 负责人: PAUL W DAVENPORT
• 金额: $ 15.42万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3367947
• 关键词: adolescence (12-20); afferent nerve; asthma; brain electrical activity; brain mapping; cerebral cortex; child (0-11); evoked potentials; human subject; neural information processing; perceptual distortions; pulmonary respiration; respiratory airflow measurement

Asthma is the most common cause of respiratory disability in children. Asthma deaths have increased worldwide. one of the common factors associated with asthma fatality is failure to recognize the severity of the asthma attack. It can result in an inappropriate, even fatal, delay in receiving treatment. The primary goal of this project is to investigate the neural and behavioral mechanisms which contribute to this failure to recognize the severity of their asthma. specifically, the physiological processes mediating respiratory sensation and subsequent behavioral responses will be studied in asthmatic children. These studies will test the hypothesis that the perception of mechanical loads is related to respiratory related evoked potentials (RREP). The significance of the work lies in the fact that impaired perception of loaded breathing may put some asthmatic patients at risk by causing underestimation of the severity of an attack with consequent inadequate self-medication and delay in seeking medical attention. In addition, the RREP may serve as a neurological means of identifying patients with respiratory load sensory deficits. The RREP is a unique measure of cerebral cortical neural activity elicited by breathing against a mechanical load. This technique will be used, in combination with established psychophysical measures, to test for differences in the neural processing of respiratory load information between asthmatic and non-asthmatic children. The cortical distribution of the RREP and resistive load threshold for eliciting the RREP during inspiration and expiration will be determined. This will be followed by correlation of the neural measure of mechanical load afferent activation (RREP amplitude) with subjective measures of load perception. Elevated background resistance, such as occurs in chronic asthma, will be used to test for the change in perceptual sensitivity. The ventilatory response to mechanical loads will also be correlated with the RREP and detection of the load. The results of this project will provide new information on the sensory mechanisms mediating respiratory sensation in asthmatic and non-asthmatic children. In addition, a subgroup of severe asthmatics will be identified that have a reduced perceptual acuity for mechanical loads. These results will be used to develop a better physiological understanding of self-assessment sensitivity in these children and used to provide enhanced treatment strategies.

哮喘是儿童呼吸道残疾的最常见原因。 哮喘死亡在全球范围内增加。常见因素之一 与哮喘死亡相关的是未能识别 哮喘发作。 它可能导致不适当，甚至致命的延迟 接受治疗。 该项目的主要目标是 研究对此有助的神经和行为机制 未能认识到其哮喘的严重程度。具体来说， 生理过程介导呼吸道和随后的生理过程 行为反应将在哮喘儿童中进行研究。 这些 研究将测试机械载荷感知的假设 与呼吸相关的诱发电位（RREP）有关。 这 这项工作的意义在于一个事实，即对 加载的呼吸可能会使一些哮喘患者造成风险 低估了攻击的严重程度，因此不足 自我药物和寻求医疗护理的延迟。 另外， RREP可以用作识别患者的神经系统手段 呼吸负荷感觉缺陷。 RREP是脑皮质神经活动的独特量度 通过针对机械负荷呼吸引起。 这项技术将是 与已建立的心理物理措施结合使用，用于测试 对于呼吸负荷信息的神经加工的差异 在哮喘和非心脏儿童之间。 皮质分布 RREP和电阻载荷阈值，以引起RREP 灵感和到期将被确定。 接下来是 机械负载传入激活的神经测量的相关性 （RREP振幅）具有负载感知的主观度量。 高架 背景电阻，例如在慢性哮喘中发生，将用于 测试感知敏感性的变化。 通风响应 机械载荷也将与RREP和检测有关 负载。 该项目的结果将提供新信息 关于哮喘呼吸道感觉的感觉机制 和非心理儿童。 另外，严重哮喘的亚组 将确定机械的感知敏锐度降低 负载。 这些结果将用于开发更好的生理 了解这些孩子的自我评估敏感性并使用 提供增强的治疗策略。