RESPIRATORY SENSATION IN NORMAL AND ASTHMATIC CHILDREN

正常儿童和哮喘儿童的呼吸感觉

• 批准号: 6537041
• 负责人: PAUL W DAVENPORT
• 金额: $ 18.06万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537041
• 关键词: adolescence (12-20); asthma; behavioral /social science research tag; brain electrical activity; brain mapping; bronchomotion; cerebral cortex; clinical research; evoked potentials; human subject; middle childhood (6-11); neural information processing; perceptual distortions; psychophysiology; pulmonary respiration; respiratory airflow measurement; sensory discrimination

DESCRIPTION (Adapted from the applicant's abstract): Asthma is the most common cause of respiratory disability in children. One of the common factors associated with asthma fatality is failure to recognize the severity of the asthma attack. This project has demonstrated that children with a history of life threatening asthma attacks (LTA) have a significantly decreased perceptual sensitivity to increased extrinsic loads and an increased threshold for detection of an increased extrinsic load. The absence of an early component, the P1 peak, or the respiratory related evoked potential (RREP) is indicative that there may be an intrinsic neural processing deficit in some children with LTA. The studies performed to date in this project demonstrate that one component of the child's failure to recognize an asthmatic attack in its early stages may be a reduced perceptual sensitivity to an increased load. The primary goal of this project is to continue the investigation of the neurophysiologic and behavioral mechanisms which may be mediating this failure of some asthmatics to recognize the severity of their asthma. Specifically, the sensory processes mediating bronchoconstriction, respiratory load perception and subsequent behavioral responses in asthmatic children. These studies will test the hypothesis that the sensation of mechanical loads is related to the components of the RREP. It is further hypothesized that the late components of the RREP are correlated with cognitive processing of respiratory loads. The significance of the work lies in the fact that impaired perception of intrinsic and extrinsic loaded breathing may put some asthmatic patients at risk of underestimation of the severity of an attack, delay in awareness of onset, inadequate self-assessment and delay in seeking medical attention. The RREP is a unique measure of cortical neural activity elicited by breathing against a mechanical load. This technique will be used, in combination with established psychophysical measures, to test for differences in the neural processing of respiratory load information between LTA, non-LTA asthmatic and non-asthmatic children. The perceptual sensitivity and interaction of different types of stimuli will be investigated. An investigation of the relationship between neural measures of mechanical load afferent activation and subjective measures of load perception will be performed. Bronchoconstriction and resistive loads will be used to test for the correlation between intrinsic and extrinsic perception. The relationship between the component peaks of the RREP and respiratory loads will be determined. The cortical activation by loads will be measured and the RREP recorded with the inclusion and exclusion of the different mechanoreceptor populations. The results of this project will provide new information on the sensory mechanisms mediating respiratory sensation in LTA asthmatic and non-asthmatic children. These results will be used to develop a better physiological understanding of self-assessment mechanisms in these children and used to provide enhanced treatment.

描述（改编自申请人的摘要）：哮喘是最常见的 导致儿童呼吸困难的原因。共同因素之一 与哮喘死亡相关的是未能认识到哮喘的严重性 哮喘发作。该项目表明，有病史的儿童 危及生命的哮喘发作 (LTA) 的知觉显着下降 对增加的外在负荷和增加的阈值的敏感性 检测到外在负载增加。由于缺乏早期成分， P1 峰值或呼吸相关诱发电位 (RREP) 具有指示性 一些患有此病的儿童可能存在内在的神经处理缺陷 陆路交通管理局。该项目迄今为止进行的研究表明， 儿童未能在早期识别出哮喘发作的一个因素 阶段可能是对增加的负载的感知敏感性降低。这 该项目的主要目标是继续调查 可能介导这种失败的神经生理和行为机制 一些哮喘患者认识到哮喘的严重程度。具体来说， 介导支气管收缩、呼吸负荷感知的感觉过程 以及哮喘儿童随后的行为反应。这些研究将 检验机械负载的感觉与相关的假设 RREP 的组成部分。进一步推测，晚期成分 RREP 与呼吸负荷的认知处理相关。这 这项工作的意义在于，内在的感知受损 外源性负荷呼吸可能会使一些哮喘患者面临以下风险： 低估发作的严重性，延迟意识到发作， 自我评估不足并延迟就医。 RREP 是 对呼吸引起的皮质神经活动的独特测量 机械负载。该技术将与已建立的技术相结合使用 心理物理测量，测试神经处理的差异 LTA、非 LTA 哮喘和非哮喘之间的呼吸负荷信息 孩子们。不同类型的知觉敏感性和相互作用 刺激将被调查。之间关系的调查 机械负荷传入激活的神经测量和主观测量 将执行负载感知。支气管收缩和阻力负荷 将用于测试内在和外在之间的相关性 洞察力。 RREP 各组分峰之间的关系 将确定呼吸负荷。负载引起的皮质激活将是 测量并记录 RREP，包括和排除 不同的机械感受器群体。该项目的成果将提供 关于介导呼吸感觉的感觉机制的新信息 LTA 哮喘和非哮喘儿童。这些结果将用于开发 对这些方面的自我评估机制有更好的生理理解 儿童并用于提供强化治疗。