RESPIRATORY SENSATION IN NORMAL AND ASTHMATIC CHILDREN

正常儿童和哮喘儿童的呼吸感觉

• 批准号: 6537041
• 负责人: PAUL W DAVENPORT
• 金额: $ 18.06万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537041
• 关键词: adolescence (12-20); asthma; behavioral /social science research tag; brain electrical activity; brain mapping; bronchomotion; cerebral cortex; clinical research; evoked potentials; human subject; middle childhood (6-11); neural information processing; perceptual distortions; psychophysiology; pulmonary respiration; respiratory airflow measurement; sensory discrimination

DESCRIPTION (Adapted from the applicant's abstract): Asthma is the most common cause of respiratory disability in children. One of the common factors associated with asthma fatality is failure to recognize the severity of the asthma attack. This project has demonstrated that children with a history of life threatening asthma attacks (LTA) have a significantly decreased perceptual sensitivity to increased extrinsic loads and an increased threshold for detection of an increased extrinsic load. The absence of an early component, the P1 peak, or the respiratory related evoked potential (RREP) is indicative that there may be an intrinsic neural processing deficit in some children with LTA. The studies performed to date in this project demonstrate that one component of the child's failure to recognize an asthmatic attack in its early stages may be a reduced perceptual sensitivity to an increased load. The primary goal of this project is to continue the investigation of the neurophysiologic and behavioral mechanisms which may be mediating this failure of some asthmatics to recognize the severity of their asthma. Specifically, the sensory processes mediating bronchoconstriction, respiratory load perception and subsequent behavioral responses in asthmatic children. These studies will test the hypothesis that the sensation of mechanical loads is related to the components of the RREP. It is further hypothesized that the late components of the RREP are correlated with cognitive processing of respiratory loads. The significance of the work lies in the fact that impaired perception of intrinsic and extrinsic loaded breathing may put some asthmatic patients at risk of underestimation of the severity of an attack, delay in awareness of onset, inadequate self-assessment and delay in seeking medical attention. The RREP is a unique measure of cortical neural activity elicited by breathing against a mechanical load. This technique will be used, in combination with established psychophysical measures, to test for differences in the neural processing of respiratory load information between LTA, non-LTA asthmatic and non-asthmatic children. The perceptual sensitivity and interaction of different types of stimuli will be investigated. An investigation of the relationship between neural measures of mechanical load afferent activation and subjective measures of load perception will be performed. Bronchoconstriction and resistive loads will be used to test for the correlation between intrinsic and extrinsic perception. The relationship between the component peaks of the RREP and respiratory loads will be determined. The cortical activation by loads will be measured and the RREP recorded with the inclusion and exclusion of the different mechanoreceptor populations. The results of this project will provide new information on the sensory mechanisms mediating respiratory sensation in LTA asthmatic and non-asthmatic children. These results will be used to develop a better physiological understanding of self-assessment mechanisms in these children and used to provide enhanced treatment.

描述（改编自申请人的摘要）：哮喘是最常见的 儿童呼吸道残疾的原因。常见因素之一 与哮喘死亡相关的是未能认识到的严重程度 哮喘发作。该项目表明，有历史的孩子 威胁生命的哮喘攻击（LTA）的感知大大减少 对增加外在负载的敏感性和增加的阈值 检测增加的外部负载。没有早期组件， P1峰或呼吸相关的诱发电位（RREP）是指示性的 某些患有的儿童可能会有 LTA。迄今为止在该项目中进行的研究表明 孩子未能在早期识别哮喘发作的部分 阶段可能是对增加负载的感知敏感性的降低。这 该项目的主要目标是继续调查 可能正在介导这种失败的神经生理和行为机制 一些哮喘患者认识到其哮喘的严重性。具体来说， 感官过程介导支气管收缩，呼吸负荷感知 以及随后的哮喘儿童行为反应。这些研究会 测试机械载荷的感觉与 RREP的组件。进一步假设 RREP与呼吸负荷的认知处理相关。这 这项工作的意义在于一个事实，即内在的看法受损 外部负荷呼吸可能会使一些哮喘患者有 低估了攻击的严重程度，延迟发病意识， 自我评估不足和寻求医疗护理的延迟。 RREP是 通过呼吸对A引起的皮质神经活动的独特度量 机械负载。将使用此技术，结合已建立 心理物理措施，测试神经加工的差异 LTA，非LTA哮喘和非偶然的呼吸负荷信息 孩子们。不同类型的知觉灵敏度和相互作用 将研究刺激。调查 机械负荷传入激活和主观测量的神经测量 将执行负载感知。支气管收缩和电阻载荷 将用于测试固有和外在的相关性 洞察力。 RREP和 将确定呼吸负荷。负载的皮质激活将是 测量并记录了RREP，包括和排除 不同的机械感受器种群。该项目的结果将提供 有关介导呼吸道感觉的感官机制的新信息 LTA哮喘和非心理儿童。这些结果将用于发展 对这些自我评估机制有更好的生理理解 儿童并用来提供增强的治疗。