BEHAVIORAL, ERP AND RCBF ASYMMETRY IN AFFECTIVE DISORDER

情感障碍中的行为、ERP 和 RBF 不对称

• 批准号: 3375855
• 负责人: GERARD E BRUDER
• 金额: $ 13.96万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-28 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375855
• 关键词: antidepressants; auditory stimulus; behavior; behavior test; bipolar depression manic phase; brain interhemispheric activity; brain mapping; cerebral dominance; clinical depression; cognition; depression; electroencephalography; evoked potentials; human subject; human therapy evaluation; lithium; mental disorder chemotherapy; mental disorder diagnosis; psychobiology; visual stimulus

Our long range goals have been to clarify the nature of the right hemisphere abnormalities in different diagnostic subtypes of affective illness, to evaluate the effects of antidepressant medications of these abnormalities and to assess the potential value of hemispheric asymmetry measures for predicting therapeutic response to treatment with antidepressants. We have made progress in identifying specific abnormalities of behavioral laterality associated with diagnostic subtypes and treatment responsive subgroups of depression. Our aims in the proposed project are not only to replicate these findings, but to expand out measurements of cortical event-related potentials (ERPs) and regional cerebral blood flow (rCBF) so as to study, more directly, the CNS mechanisms that might underlie alterations in cerebral laterality in affective disorders. The clinical significance of this research lies in the need for more precise diagnostic tests that could serve as predictors of treatment outcome with specific antidepressants. We propose to test a sample of 150 depressed outpatients on a brief test battery consisting of the dichotic listening tasks that show promise of being predictors of clinical response to a tricyclic antidepressant (TCA). Half of these patients will be tested on a long test battery. This includes temporal and spatial discrimination tasks during which ERPs are measured and visual tachistoscopic tasks. ERPs will also be measured during the Complex Tone Test that appears to be our most sensitive measure of laterality differences between diagnostic and treatment responsive subgroups. In addition, 50 of these depressed patients will receive rCBF tests. The patients are tested after a minimum drug-free period of 10 days and retested following 6 weeks of treatment with either a TCA, MAOI or placebo. Clinical responders are tested again on the dichotic tasks after 12 weeks of treatment. Normal controls (N=30) will be tested at the same test-retest intervals as patients. We also propose to test 60 inpatients having bipolar disorders with mania. Our aims here are to confirm preliminary evidence of an association between dichotic asymmetry and response to treatment with lithium, and to further investigate changes in hemispheric asymmetry in manic as compared to euthymic states.

我们的远程目标是阐明权利的本质 不同诊断亚型的半球异常 情感疾病，评估抗抑郁药的影响 这些异常的药物并评估潜力 预测半球不对称度量的价值 对用抗抑郁药治疗的治疗反应。 我们有 在识别特定行为异常方面取得了进展 与诊断亚型和治疗相关的侧向 抑郁症的反应性亚组。 我们的目标 项目不仅是为了复制这些发现，而且要扩大 皮质事件相关电位（ERP）和 区域脑血流（RCBF），以便更直接地研究 CNS机制可能是大脑改变的基础 情感障碍中的横向性。 临床意义 研究在于需要更精确的诊断测试 可以用作特定的治疗结果的预测指标 抗抑郁药。 我们建议在A上测试150个抑郁门诊患者的样本 简短的测试电池由二分法听力任务组成 显示出成为对临床反应的预测指标的希望 三环抗抑郁药（TCA）。 这些患者中有一半是 在长期测试电池上进行了测试。 这包括时间和空间 在测量ERP和视觉的歧视任务中 Tachistossoscic任务。 ERP也将在 复杂的音调测试似乎是我们最敏感的措施 诊断和治疗之间的横向差异 响应式亚组。 此外，其中50例抑郁症患者 将收到RCBF测试。 最低后对患者进行测试 无药物为10天，在6周后进行了重新测试 用TCA，MAOI或安慰剂治疗。 临床 12周后，再次对响应者进行二分法的测试 治疗。 正常对照（n = 30）将在相同的 重度时间间隔作为患者。 我们还建议测试60名患有双极疾病的住院患者 躁狂。 我们在这里的目的是确认 二分法不对称和对 用锂治疗，并进一步研究 与整齐状态相比，躁狂中的半球不对称性。