CONTROL OF THE RESPIRATORY SYSTEM BY THE HYPOTHALAMUS

下丘脑对呼吸系统的控制

• 批准号: 3355067
• 负责人: TONY G WALDROP
• 金额: $ 7.19万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3355067
• 关键词: antiadrenergic agents; baroreceptors; cats; chemical stimulation; chemoreceptors; electrostimulus; experimental brain lesion; hypothalamus; microinjections; neural information processing; neurochemistry; neuropharmacology; neurotransmitters; respiration regulatory center; respiratory function; respiratory reflex; single cell analysis; stretch reflex

The purpose of the research in this proposal is to investigate hypothalamic involvement in the control of the respiratory system. Several studies have demonstrated that areas in the hypothalamus are involved in modulating some cardiovascular reflexes. For example, the cardiovascular responses to stimulation of baroreceptors and peripheral chemoreceptors are known to be modified by sites in the hypothalamus. Even though activation of these receptors also affects ventilation, almost no research has examined a role of the hypothalamus in regulating respiratory responses. Therefore, the specific aims of the studies described in this proposal are to investigate a potential role of hypothalamic sites in regulating respiratory reflexes and to determine the neurotransmitters utilized by the hypothalamic sites which modulate breathing. The respiratory reflexes to be studied are those evoked by stimulation of 1) pulmonary stretch receptors (Hering-Breuer reflex); 2) peripheral chemoreceptors; 3) central chemoreceptors and 4) arterial baroreceptors. Three sets of experiments will be performed in anesthetized cats. First, the effects of changing the "excitability state" of neurons in selected hypothalamic sites upon the respiratory reflexes will be determined. The excitability state will be raised by chemical or electrical stimulation and will be lowered by electrolytic lesions or by focal cooling of hypothalamic sites. In a second set of experiments the effects upon the respiratory reflexes of microinjecting neurotransmitter antogonists into the hypothalamus will be evaluated. Finally, it will be determined if the respiratory stimuli listed above alter the discharge frequency of hypothalamic neurons. The information gained from these experiments should add to the overall understanding of the neural control of respiration. These findings may offer insights into the neurological abnormalities responsible for some central respiratory disorders.

该提案中研究的目的是调查 下丘脑参与呼吸系统 系统。 几项研究表明， 下丘脑参与调节一些心血管 反射。 例如，心血管对 刺激压力感受器和周围化学感受器是 已知可以通过下丘脑中的位点进行修饰。 虽然 这些受体的激活也会影响通风，几乎没有 研究检查了下丘脑在调节中的作用 呼吸反应。 因此，研究的具体目的 该提案中描述的是研究 调节呼吸反射的下丘脑部位和 确定下丘脑使用的神经递质 调节呼吸的部位。 呼吸反射为 研究的是刺激1）肺拉伸的刺激 受体（Hering-Breuer反射）； 2）外周化学感受器； 3） 中央化学感受器和4）动脉压力感受器。 三组 实验将在麻醉猫中进行。 首先， 改变所选神经元的“兴奋性状态”的影响 呼吸反射的下丘脑部位将是 决定。 兴奋性状态将通过化学或 电刺激，将通过电解病变降低 或通过局灶性冷却下丘脑位点。 在第二组 实验对呼吸反射的影响 微注射神经递质antogonists进入 下丘脑将进行评估。 最后，将确定是否 上面列出的呼吸刺激改变了放电频率 下丘脑神经元。 从这些中获得的信息 实验应增加对神经的整体理解 控制呼吸。 这些发现可能会提供有关 导致某些中心的神经异常 呼吸系统疾病。