Signal Amplification in NMR and MRI using hyperpolarised compounds

使用超极化化合物放大 NMR 和 MRI 中的信号

• 批准号: EP/H029575/1
• 负责人: S Duckett
• 金额: $ 9.75万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH029575%2F1
• 关键词: Signal; Amplification; NMR; MRI; using

The NMR Centre and the Neuroimaging Centre at the University of York have conducted a programme of work that has demonstrated that one of the fundamental limitations of conventional Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) techniques can be dramatically overcome. NMR is the most popular method for performing analytical and structural chemistry and MRI is the technique of choice for carrying out non-invasive imaging in humans. Even though the global markets for these techniques exceeds 6billion annually, as identified in a recent US report to Congress, both technologies are limited in application due to poor sensitivity. A process termed hyperpolarisation, developed in York throughout the last decade, allows these limitations to be overcome. We have recently shown that 0.5 seconds worth of data collection equates to 58 days on the conventional device.In laymen's terms, both NMR and MRI deal with the probing of the magnetic behaviour of nuclei within molecules. These nuclei behave like bar magnets and therefore can either have a north or south seeking orientation. Parahydrogen is simply a reaction feedstock where rather than having a mixture of such orientations, we start with a pure magnetic form. We have established a new route to utilising this feedstock in MR studies. The parahydrogen simply acts like a radiator which when brought into contact with its surroundings warms the room. In this case, the result is a potential 31,000 increase in detected signal strength. The information obtained through MIR studies is well established as providing critical information related to diagnosis and treatment in the health field. The breakthrough in sensitivity enhancement offers opportunities for a step change in modern healthcare and in high resolution NMR markets. This is achieved without the chemical modification of a material and it can employ substances that are native to the body. We therefore expect that it will not suffer from the toxicological problems associated with gadolinium contrast agents and PET and hence be well received by the medical community and laymen alike.Please see Proposal Form for details

约克大学的NMR中心和神经影像中心已经进行了一项工作计划，该计划表明，常规核磁共振（NMR）和磁共振成像（MRI）技术的基本局限性之一可以极大地克服。 NMR是进行分析和结构化学的最流行方法，MRI是在人类中进行非侵入性成像的首选技术。尽管这些技术的全球市场每年超过60亿美元，正如美国最近向国会的一份报告所述，由于敏感性不佳，两种技术的应用都受到限制。在过去的十年中，在约克开发的一种称为超极化的过程允许克服这些局限性。我们最近表明，在传统设备上，价值0.5秒的数据收集等于58天。在外行的项中，NMR和MRI都涉及分子内核的磁性行为的探测。这些核的行为就像棒磁铁一样，因此可以具有北方或南方寻求方向。寄生虫只是一种反应原料，我们从纯磁性形式开始，而不是具有这种方向的混合物。我们已经在MR研究中建立了一条新的途径来利用此原料。寄生虫的作用就像散热器一样，当与周围环境接触时，房间温暖。在这种情况下，结果是检测到的信号强度的潜在增加了31,000。通过MIR研究获得的信息已被良好确定为提供与健康领域诊断和治疗有关的关键信息。灵敏度增强的突破为现代医疗保健和高分辨率NMR市场的逐步变化提供了机会。这是在没有材料化学修饰的情况下实现的，它可以采用原生体的物质。因此，我们预计它不会遭受与Gadolinium对比剂相关的毒理学问题，因此医学界和外行都将受到宠物的好处。请参见提案表格。

项目成果

Iridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions.

• DOI: 10.1021/ic401783c
• 发表时间: 2013-12-02
• 期刊: Inorganic chemistry
• 影响因子: 4.6
• 作者: Fekete M;Bayfield OW;Duckett SB;Hart S;Mewis RE;Pridmore N;Rayner PJ;Whitwood A
• 通讯作者: Whitwood A

Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen.

• DOI: 10.1039/c5sc00756a
• 发表时间: 2015-07-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Appleby KM;Mewis RE;Olaru AM;Green GGR;Fairlamb IJS;Duckett SB
• 通讯作者: Duckett SB

Improving NMR and MRI sensitivity with parahydrogen.

使用仲氢提高 NMR 和 MRI 灵敏度。

• DOI: 10.1007/128_2012_388
• 发表时间: 2013
• 期刊: Topics in current chemistry
• 影响因子: 8.6
• 作者: Duckett SB

Improving the hyperpolarization of (31)P nuclei by synthetic design.

• DOI: 10.1021/acs.jpcb.5b00686
• 发表时间: 2015-04-16
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Burns, Michael J.;Rayner, Peter J.;Green, Gary G. R.;Highton, Louise A. R.;Mewis, Ryan E.;Duckett, Simon B.
• 通讯作者: Duckett, Simon B.