MULTIPLE CARDIAC INPUTS TO ASCENDING PATHWAYS

多种心脏输入上升通道

• 批准号: 3337039
• 负责人: ROBERT D FOREMAN
• 金额: $ 14.91万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-12-01 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3337039
• 关键词: afferent nerve; analgesia; angina pectoris; antidromic impulse; brain mapping; brain stem; cardiovascular pharmacology; electrophysiology; electrostimulus; heart pharmacology; microelectrodes; myocardial ischemia /hypoxia; neuroanatomy; pain; reticular formation; somesthetic sensory cortex; spinal nerves; thalamus

Cardiovascular adjustments and pain sensation usually occur when an organism encounters a "painful stimulus" associated with ischemia and infarction of the heart, but sometimes the insult does not produce pain (i.e. the "silent infarct"). The intermediate and long term objectives are to record activity of cells of origin of the spinoreticular tract (SRT) and the medial and lateral spinothalamic tract (STT) system, of the thalamus, and of the somatosensory cortex and examine the complex interactions that occur between the cardiovascular system, particularly the heart, and the pain system. The working hypothesis of this proposal is that activation of vagal afferent fibers stimulates brainstem structures whose projections descend to modulate the activity of SRT and STT neurons in the T1-T5 segments of the spinal cord. The upper thoracic spinal cord of cats (SRT cells) and monkey (STT cells) will be explored with carbon filament or tungsten microelectrodes to record single extracellular action potentials of cells antidromically activated from the thalamus or the medullary reticular formation. The specific aims are to: 1) determine effects of electrically, mechanically or chemically stimulating vagal afferent fibers on activity of SRT and STT cells responding to visceral and somatic inputs; 2) determine nuclei and descending pathways activated during vagal stimulation by applying focal electrical and chemical stimulation and by making lesions; 3) simultaneously record activity of raphe-spinal and STT and SRT cells during vagal stimulation; and 4) examine the effects of independently occluding branches of the left coronary artery and the right coronary artery on the activity of STT or SRT cells before and after vagal cooling or vagal stimulation. This study will contribute to understanding the interactions of neural mechanisms that underlie cardiac pain, the associated angina pectoris and possibly the "silent infarction".

通常，当心血管调节和疼痛感时通常发生 有机体遇到与缺血和相关的“痛苦刺激”和 心脏梗塞，但有时侮辱不会产生痛苦 （即“沉默的梗塞”）。 中间和长期目标是 记录甲状腺图（SRT）的起源细胞活性和 丘脑的内侧和外侧脊柱丘脑（STT）系统， 以及体感皮层的，并检查了复杂的相互作用 发生在心血管系统之间，尤其是心脏和 疼痛系统。 该提议的工作假设是激活 迷走神经传入纤维刺激其预测的脑干结构 降低T1-T5中SRT和STT神经元的活性 脊髓段。 猫的上胸脊髓（SRT 细胞）和猴子（STT细胞）将用碳丝或 钨微电极记录单个细胞外动作电位 从丘脑或髓质激活的细胞抗肿瘤的细胞 网状形成。 具体目的是：1）确定 电气，机械或化学刺激迷走神经传入纤维 关于响应内脏和体细胞输入的SRT和STT细胞的活性； 2）确定在迷走神经期间激活的核和下降途径 通过应用焦点电气和化学刺激以及通过 制造病变； 3）同时记录Raphe-Spinal和STT的活性 迷走神经刺激期间的SRT细胞； 4）检查 独立阻塞左冠状动脉和右侧的分支 迷走神经前后的冠状动脉对STT或SRT细胞活性 冷却或迷走神经刺激。 这项研究将有助于理解 心脏疼痛的神经机制的相互作用， 相关的心绞痛，可能是“无声梗塞”。